76 products were found matching "K02516"!

MRTX1719 is an inhibitor of the PRMT5/MTA complex and may be effective against MTAP-deleted cancers. SMILES: CN1C(=C(C=N1)C2=CC3=C(C=C2)C(=O)NN=C3CN)C4=C(C(=CC(=C4F)Cl)OC5CC5)C#N

MRTX-1719 is an inhibitor of the protein arginine methyltransferase 5 (PRMT5) and methylthioadenosine (MTA) complex. It selectively binds to the PRMT5/MTA complex over the PRMT5 and S-adenosyl-L-methionine (SAM) complex (Kds = 0.14 and 9.4 pM, respectively). MRTX-1719 selectively decreases protein dimethylarginine...

Description: GSK3326595 (EPZ015938) is an inhibitor of protein arginine methyltransferase 5 (PRMT5)(IC50:6.2 nM.). Target: Histone Methyltransferase. Smiles: CC(=O)N1CCC(CC1)Nc1cc(ncn1)C(=O)NC[C@@H](O)CN1CCc2ccccc2C1. References: Gerhart S V , Kellner W A , Christine T , et al. Activation of the p53-MDM4 regulatory...

Description: GSK591 (GSK3203591), Alternative Names are EPZ015866, GSK3203591, is a potent selective inhibitor of the arginine methyltransferase PRMT5 (IC50=11 nM). Target: Histone Methyltransferase. Smiles: O[C@@H](CNC(=O)c1ccnc(NC2CCC2)c1)CN1CCc2ccccc2C1. References: Elayne Chan-Penebre, et al. Nat Chem Biol....

Description: HLCL-61 hydrochloride (HLCL-61 HCL) is a potent and selective PRMT5 inhibitor for the treatment of acute myeloid leukemia. Target: Apoptosis, Histone Methyltransferase. Smiles: Cl.CCn1c2ccccc2c2cc(CNCc3ccccc3OC)ccc12. References: Tarighat SS, et al. Leukemia. 2016, 30(4):788-799.

Description: EPZ015666 (GSK3235025) is an orally available inhibitor of PRMT5 enzymatic activity. Target: Histone Methyltransferase. Smiles: O[C@@H](CNC(=O)c1cc(NC2COC2)ncn1)CN1CCc2ccccc2C1. References: Penebre et al. Epizyme, Inc.

Description: LLY-283 is a potent, selective, and oral protein arginine methyltransferase 5 (PRMT5) inhibitor, exhibiting an IC50 of 22 nM and a Kd of 6 nM for the PRMT5:MEP50 complex, and demonstrates antitumor activity. Target: Histone Methyltransferase. Smiles:...

Description: JNJ-64619178 is a selective, orally active, and pseudo-irreversible inhibitor of protein arginine methyltransferase 5 (IC50: 0.14 nM). It has effective activity In lung cancer. Target: Histone Methyltransferase. Smiles: Nc1nc2cc(CC[C@H]3C[C@H]([C@H](O)[C@@H]3O)n3ccc4c(N)ncnc34)ccc2cc1Br. References:...

Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: PRMT5. Antigen Species: Human

Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: PRMT5. Antigen Species: Human

Protein function: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA (PubMed:10531356, PubMed:11152681, PubMed:11747828, PubMed:12411503, PubMed:15737618, PubMed:17709427,...

Active human PRMT5 (GenBank Accession No. NM_006109), amino-acids 2-end, with N-terminal DDDDK tag (FLAG), MW=73 kDa, expressed in a FreeStyle 293-F cells.