51 products were found matching "K02469"!

Ciprofloxacin is a fluoroquinolone antibiotic. It is active against a variety of Gram-positive and Gram-negative bacteria in vitro, including S. aureus, L. monocytogenes, P. aeruginosa, Legionella, N. gonorrhoeae, and H. pylori (MIC50s = 0.004-1 µg/ml). It is also active against clinical isolates of Bacteroides,...

Moxifloxacin-d4 is intended for use as an internal standard for the quantification of moxifloxacin (Cay-14830) by GC- or LC-MS. Moxifloxacin is a fluoroquinolone antibiotic that is active through multiple routes of administration. Formulations containing moxifloxacin have been used to treat bacterial infections...

Antibiotic, Bacterial DNA gyrase inhibitor: Staphylococcus aureus (IC50= 1.45µM), E.coli (IC50= 0.41µM), Human topoisomerase II (Topo II) inhibitor (IC50= 100µM), Antibacterial (Gram-positive), Antitumor compound. Isolated from Streptomyces antibioticus Tü 6040.

Bacterial DNA gyrase is a heterodimeric type II topoisomerase that negatively supercoils circular double-stranded DNA. Oxolinic acid is a quinolone antibiotic that inhibits bacterial DNA gyrase, but not eukaryotic topoisomerases, reversibly binding gyrase subunit A in gyrase-DNA complexes, blocking supercoiling...

Nalidixic acid is a quinolone antibiotic. It is active against E. coli, Pasturella, K. pneumoniae, A. aerogenes, Proteus, Salmonella, and Shigella with minimum bacteriostatic concentrations (MBCs) ranging from 0.5 to 25 µg/ml. Nalidixic acid increases survival in mouse models of systemic K. pneumoniae, A. aerogenes,...

Novobiocin is an antibiotic and inhibitor of HSP90. Also inhibits DNA gyrase and retrovirus RNA-dependent DNA polymerase. Useful for the production of positively supercoiled plasmid DNA.

Gatifloxacin is a fluoroquinolone antibiotic which inhibits bacterial DNA gyrase (IC50 = 0.109 µg/ml) and topoisomerase IV (IC50 = 13.8 µg/ml). It is much less effective against HeLa cell topoisomerase II (IC50 = 265 µg/ml). Gatifloxin has been used as a broad-spectrum oral antibiotic, but it can produce dysglycemia...

Tosufloxacin is a fluoroquinolone antibiotic. It has activity against diverse aerobic and anaerobic bacteria in vitro. Tosufloxacin is also effective against bacterial persisters, showing significant activity against S. aureus and uropathogenic E. coli persisters. As with many other quinolones, tosufloxacin use can...

Levofloxacin is a fluoroquinolone antibiotic and the active stereoisomer of ofloxacin (Cay-22891). It is active against S. aureus, S. epidermidis, B. subtilis, E. coli, P. aeruginosa, and K. pneumoniae (MICs = 0.25, 0.25, 0.5, 0.03, 4, and 0.25 µg/ml, respectively). Levofloxacin inhibits S. aureus DNA gyrase and...

Temafloxacin is a fluoroquinolone antibiotic that acts as a DNA topoisomerase inhibitor. It has broad antimicrobial activity against gram-positive and gram-negative bacteria, such as S. pneumoniae, M. hominis, and anaerobic bacteria, including B. fragilis.Formal Name:...

Sarafloxacin is a fluoroquinolone antibiotic. It is active against various clinical isolates of bacteria, including Bacteroides, Fusobacterium, Eubacterium, Actinomyces, and Peptococcus (MICs = 0.5-2 µg/ml). Sarafloxacin inhibits P. aeruginosa DNA gyrase. It decreases air sac lesion severity in a chick model of E....

Ciprofloxacin-d8 is intended for use as an internal standard for the quantification of ciprofloxacin (Cay-14286) by GC- or LC-MS. Ciprofloxacin is a fluoroquinolone antibiotic. It is active against a variety of Gram-positive and Gram-negative bacteria in vitro, including S. aureus, L. monocytogenes, P. aeruginosa,...