23 products were found matching "K02320"!

Cytarabine (ara-C) is a nucleoside analog and prodrug form of the DNA polymerase inhibitor ara-CTP. It is triphosphorylated to ara-CTP by the successive actions of deoxycytidine kinase, deoxycytidylate kinase, and nucleoside diphosphate kinase. Ara-C inhibits proliferation of HL-60, ML-1, Raji, and Jurkat human...

Description: Aphidicolin, an antibiotic derived from the mold Cephalosporium aphidicola, is a potent inhibitor of DNA (deoxyribonucleic acid) synthesis, effectively hindering the proliferation of herpes simplex virus[2]. It targets DNA polymerase alpha and delta, disrupting mitotic cell division by affecting DNA...

Description: CX-5461, a selective inhibitor of rRNA synthesis, suppresses Pol I-driven transcription of rRNA. Target: DNA/RNA Synthesis. Smiles: CN1CCCN(CC1)c1ccc2c(n1)n1c3ccccc3sc1c(C(=O)NCc1cnc(C)cn1)c2=O. References: Drygin D, et al, Cancer Res, 2011, 71(4), 1418-1430.

Description: POLA1 inhibitor 1 (Compound 12) is an orally active inhibitor of POLA1, displaying antitumor effects on various tumor tissue types and Adaroten-resistant cell lines. Target: Others. Smiles: O\N=C\c1cc(\C=C\C(O)=O)ccc1-c1ccc(O)c(c1)C12CC3CC(CC(C3)C1)C2

Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...

Host Species: Rabbit. Isotype: IgG. Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by...

Antibiotic, Reversible inhibitor of eukaryotic nuclear DNA replication, Useful for cell synchronization, Blocks the cell cycle at early S phase, Prolongs the half life of DNA methyltransferase, Specific DNA polymerase alpha and delta inhibitor in eukaryotic cells and in some viruses of animal origin, Acts...

CX-5461 is an inhibitor of ribosomal RNA (rRNA) synthesis. It selectively inhibits RNA polymerase I-driven transcription of rRNA in HCT116, A375, and MIA PaCa-2 tumor cells (IC50s = 142, 113, and 54 nM, respectively) without affecting RNA polymerase II (IC50 > 25µM), DNA replication, or protein translation. At 50...

Protein function: Plays an essential role in the initiation of DNA replication. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1/p180, a regulatory subunit POLA2/p70 and two primase subunits PRIM1/p49 and PRIM2/p58) is recruited to DNA at the replicative...

White solid. A DNA polymerase inhibitor. Potentiates apoptosis induced by therapeutic nucleosides.

Cytarabine is an antimetabolite compound which is proven to be one of the most effective agents available to treat leukemia. It induces its cytotoxic effect by inactivating DNA polymerases alpha, delta, and epsilon and consequently inhibit semi-conservative DNA replication and repair. It also has a potential to...

Cytarabine-13C3 (ara-C-13C3) is intended for use as an internal standard for the quantification of ara-C (Cay-16069) by GC- or LC-MS. Ara-C is a nucleoside analog and prodrug form of the DNA polymerase inhibitor ara-CTP. It is triphosphorylated to ara-CTP by the successive actions of deoxycytidine kinase,...