107 products were found matching "K02089"!
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Anti-CDK4
Item number: ABS-KC-353.100
Protein function: Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F...
| Keywords: | Anti-Cyclin-dependent kinase 4, Anti-Cell division protein kinase 4, Anti-PSK-J3, CDK4 Antibody |
| Host: | Mouse |
| Species reactivity: | human |
From 232.00€
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CDK4 Protein, Human, Recombinant (His)
Item number: TGM-TMPH-01169-100ug
Description: CDK4 Protein, Human, Recombinant (His) is expressed in E. coli.
| Keywords: | CDK4, Cyclin-dependent kinase 4, Cell division protein kinase 4, PSK-J3 |
| MW: | 37.6 kD |
From 198.00€
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Palbociclib hydrochloride
Item number: TGM-T63576-2mg
Description: Palbociclib (PD 0332991) hydrochloride is a selective and potent inhibitor of CDK4 (IC50: 11 nM) and CDK6 (IC50: 16 nM). It exerts anti-proliferative effects on cancer cells, inducing cell cycle arrest, and can be used in research on HR-positive and HER2-negative breast cancer, as well as hepatocellular...
| Application: | CDK4 / CDK6 inhibitor |
| CAS | 571189-11-2 |
| MW: | 514.99 D |
From 31.00€
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AMG 925
Item number: TGM-T6756-10mg
Description: AMG 925 is a potent and orally bioavailable dual FLT3/CDK4 inhibitor with IC50 of 1 nM and 3 nM, respectively. Target: CDK, FLT. Smiles: C[C@H]1CC[C@@H](CC1)n1c2cnccc2c2cnc(Nc3ccc4CN(CCc4n3)C(=O)CO)nc12. References: Xiaoqi Chen, et al. Fused tricyclic dual inhibitors of cdk 4/6 and flt3. WO 2012129344 A1
| Application: | FLT3 / Cdk4 dual inhibitor |
| CAS | 1401033-86-0 |
| MW: | 471.55 D |
From 31.00€
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Palbociclib monohydrochloride
Item number: TGM-T6239-100mg
Description: Palbociclib monohydrochloride (PD 0332991 hydrochloride) is a selective inhibitor of CDK4/6 (IC50s: 11/16 nM). It exhibits no inhibition against a panel of 36 additional protein kinases. Target: CDK. Smiles: Cl.CC(=O)c1c(C)c2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n(C2CCCC2)c1=O. References: Fry DW, et al. Specific...
| Keywords: | PD 0332991 hydrochloride, Palbociclib hydrochloride, Palbociclib (PD-0332991) HCl |
| Application: | Cyclin-dependent kinase 4/6 (CDK4/6) inhibitor |
| CAS | 827022-32-2 |
| MW: | 483.99 D |
From 48.00€
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Abemaciclib methanesulfonate
Item number: TGM-T3111-2mg
Description: Abemaciclib methanesulfonate (LY2835219) is a specific and effective inhibitor of CDK4(IC50=2 nM) and CDK6(IC50=10 nM). Target: CDK. Smiles: CS(O)(=O)=O.CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C(C)C)c4c3)nc2)CC1. References: Sanchez-Martinez et al. Mol Cancer Ther, 2011,10(11 Suppl), Abstract nr...
| Keywords: | LY2835219, abemaciclib mesylate, LY2835219 mesylate, LY2835219 (methanesulfonate) |
| Application: | CDK4 / CDK6 inhibitor |
| CAS | 1231930-82-7 |
| MW: | 602.7 D |
From 31.00€
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Trilaciclib hydrochloride
Item number: TGM-T13202-100mg
Description: Trilaciclib hydrochloride (G1T28 hydrochloride) is an inhibitor of CDK4/6 (IC50s: 1 nM and 4 nM for CDK4 and CDK6). Target: CDK. Smiles: Cl.Cl.CN1CCN(CC1)c1ccc(Nc2ncc3cc4C(=O)NCC5(CCCCC5)n4c3n2)nc1. References: Bisi JE, et al. Preclinical Characterization of G1T28: A Novel CDK4/6 Inhibitor for Reduction...
| Keywords: | G1T28 hydrochloride |
| Application: | Cdk4 / Cdk6 inhibitor |
| CAS | 1977495-97-8 |
| MW: | 519.47 D |
From 31.00€
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GP-82996
Item number: TGM-T21720-1mg
Description: GP-82996 (CINK4) is a pharmacological inhibitor specifically targeting CDK4/6, exhibiting IC50 values of 1.5 µM for CDK4/cyclin D1, 5.6 µM for CDK6/cyclin D1, and 25 µM for Cdk5/p35. It effectively induces apoptosis in U2OS cancer cells, positioning it as a potential investigational tool in cancer...
| Keywords: | Cdk4/6 Inhibitor IV, CINK4 |
| Application: | Cdk4/cyclin D1 inhibitor, Cdk6/cyclin D1 inhibitor |
| CAS | 359886-84-3 |
| MW: | 456.58 D |
From 48.00€
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Fascaplysin chloride
Item number: TGM-T27305-1mg
Description: Fascaplysin is a cyclin D kinase 4/ cyclin D1 inhibitor (IC50 = 0.35 µM). Fascaplysin induces caspase mediated crosstalk between autophagy and apoptosis through the inhibition of PI3K/AKT/mTOR signaling cascade in human leukemia HL-60 cells. Target: Others. Smiles:...
| Keywords: | NSC 622398, NSC622398, Fascaplysin, NSC-622398 |
| Application: | CDK4/cyclin D1 inhibitor |
| CAS | 114719-57-2 |
| MW: | 306.75 D |
From 122.00€
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Cdk4 Inhibitor
Item number: TGM-T84413-10mg
Description: PD 0332991, an unsymmetrical indolocarbazole compound, is cell-permeable and exhibits antiproliferative effects by functioning as a potent, selective, reversible, and ATP-competitive inhibitor of Cdk4/D1 (IC 50 = 76 nM). Although it can inhibit other Cdks, such as Cdk2/E and Cdk1/B, effectiveness...
| Keywords: | Cyclin-dependent kinase 4 Inhibitor |
| Application: | Cdk4 inhibitor |
| CAS | 546102-60-7 |
| MW: | 404.2 D |
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Anti-CDK4
Item number: CSB-PA005118.100
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
| Keywords: | Anti-CDK4, Anti-PSK-J3, EC=2.7.11.22, Anti-Cyclin-dependent kinase 4, Anti-Cell division protein kinase 4, Cdk 4 antibody,... |
| Application: | ELISA, WB |
| Host: | Rabbit |
| Species reactivity: | human, mouse, rat |
From 126.00€
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Anti-CDK4
Item number: CSB-PA11659A0Rb.100
Host Species: Rabbit. Isotype: IgG. Buffer: Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: >95%, Protein G purified. Target Name: CDK4. Antigen Species: Human
| Keywords: | Anti-CDK4, Anti-PSK-J3, EC=2.7.11.22, Anti-Cyclin-dependent kinase 4, Anti-Cell division protein kinase 4, Cdk 4 antibody,... |
| Application: | ELISA, IHC |
| Host: | Rabbit |
| Species reactivity: | human |
From 167.00€
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