188 products were found matching "K02087"!
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TG003
Item number: Cay10398-1
Cdc2-like kinase (Clk), among a number of other kinases, phosphorylates serine/arginine-rich proteins which play a role in alternative splicing of pre-mRNA. The Clk family consists of four members, which include Clk1/Sty and Clk2-4. TG003 is a novel benzothiazole compound that demonstrates potent inhibition of...
| Keywords: | 1-(3-ethyl-5-methoxy-2(3H)-benzothiazolylidene)-2-propanone |
| Application: | Cdc2 kinase inhibitor |
| CAS | 300801-52-9 |
| MW: | 249.3 D |
From 32.00€
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(S)-Roscovitine
Item number: AG-MR-C0002-M005
Soluble in DMSO, ethanol or methanol. Stock solutions can be made up to 10 mM in DMSO. (S)-enantiomer of (R)-roscovitine (Prod. No. MR-C0001). Potent selective cyclin-dependent kinase 1 (CDK1) inhibitor. Potential neuroprotectant for stroke. Crosses the blood brain barrier. Inhibits CDK5, consequently blocking...
| Keywords: | 6-Benzylamino-2-(S)-[(1-ethyl)-2-hydroxyethylamino]-9-isopropylpurine |
| Application: | CDK1 inhibitor |
| CAS | 186692-45-5 |
| MW: | 354,5 D |
From 116.00€
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Cdk1/2 Inhibitor III
Item number: TGM-T14914-100mg
Description: Cdk1/2 Inhibitor III is a selective inhibitor of Cdk1/2 with an IC50 value of 2.1 µM against CDK1/cyclin B. Target: CDK. Smiles: C(NC1=C(F)C=CC=C1F)(=S)N2C(NC3=CC=C(S(N)(=O)=O)C=C3)=NC(N)=N2. References: Lin R, et al. Acyl-1H-[1,2,4]triazole-3,5-diamine analogues as novel and potent anticancer...
| Application: | Cdk1/2 inhibitor |
| CAS | 443798-55-8 |
| MW: | 425.44 D |
From 348.00€
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CGP60474
Item number: TGM-T14943-100mg
Description: CGP60474 is an inhibitor of VEGFR-2 (IC50 = 84 nM) and an inhibitor of ATP-competitive PKC. CGP60474 is also a highly potent anti-endotoxemic agent and inhibits cyclin-dependent kinase (CDK) potently. Target: CDK, PKC, VEGFR. Smiles: OCCCNc1cc(ccn1)-c1ccnc(Nc2cccc(Cl)c2)n1. References: Kuo GH, et al....
| Application: | CDK inhibitor |
| CAS | 164658-13-3 |
| MW: | 355.82 D |
From 31.00€
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RP-106
Item number: TGM-T24734-1mg
Description: RP-106 is an ATP-competitive inhibitor of CDK5/p25, CDK1/cyclin B, and GSK-3. Target: Others. Smiles: C(CCC)C1=C(NC=2C1=NC=CN2)C3=CC=C(OC)C=C3. References: Dong B, Chen J, Zhang X, Pan Z, Bai F, Li Y. Two novel PRP31 premessenger ribonucleic acid processing factor 31 homolog mutations including a...
| Keywords: | RP 106 |
| Application: | CDK1/cyclin B inhibitor |
| CAS | 496864-15-4 |
| MW: | 281.35 D |
From 83.00€
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AZD-5597
Item number: TGM-T21544-1mg
Description: AZD-5597 ((S)-(4-((5-Fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimidin-2-yl)amino)phenyl)(3-(methylamino)pyrrolidin-1-yl)methanone) is a potent imidazole pyrimidine amide CDK inhibitor. Target: CDK. Smiles: CN[C@H]1CCN(C1)C(=O)c1ccc(Nc2ncc(F)c(n2)-c2cnc(C)n2C(C)C)cc1. References: Jones C D ,...
| Keywords: | (S)-(4-((5-Fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimidin-2-yl)amino)phenyl)(3-(methylamino)pyrrolidin-1-yl)met... |
| Application: | Cdk1 / Cdk2 inhibitor |
| CAS | 924641-59-8 |
| MW: | 437.51 D |
From 52.00€
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BMS-265246
Item number: TGM-T2679-100mg
Description: BMS-265246 is a potent and selective CDK1/2 inhibitor. Its chemical name is (4-[R-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-1H-indol-1-yl]-1H-pyrazolo[3,4-d] pyrimidine-6-amine), and it functions by targeting CDK1 and CDK2 to potentially disrupt cell cycle progression. Target: CDK. Smiles:...
| Keywords: | BMS265246 |
| Application: | Cell-permeable Cdk1/cyclin B & Cdk2/cyclin E inhibitor |
| CAS | 582315-72-8 |
| MW: | 345.34 D |
From 31.00€
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SB1317
Item number: TGM-T2653-2mg
Description: SB1317 (TG02) is a potent inhibitor of cyclin dependant kinases (CDKs), Janus kinase 2 (JAK2), and Fms-like tyrosine kinase-3 (FLT3). Target: CDK, FLT, JAK. Smiles: CN1C\C=C\CCOc2cccc(c2)C2=CC=N\C(N2)=N\c2cccc(C1)c2. References: William AD, et al. Discovery of kinase spectrum selective macrocycle...
| Keywords: | TG02 |
| Application: | Targets cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23] (CDK1, CDC2) |
| CAS | 1204918-72-8 |
| MW: | 372.46 D |
From 63.00€
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AT7519
Item number: TGM-T6205-100mg
Description: AT7519 is a CDK1/2/4/6/9 inhibitor (IC50: 10-210 nM). It is less effective to CDK3 and little active to CDK7. Target: CDK, GSK-3, Apoptosis. Smiles: N(C(=O)C1=C(Cl)C=CC=C1Cl)C=2C(C(NC3CCNCC3)=O)=NNC2. References: Squires MS, et al. Mol Cancer Ther, 2009, 8(2), 324-332.
| Application: | ATP competitive CDK inhibitor |
| CAS | 844442-38-2 |
| MW: | 382.24 D |
From 52.00€
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Flavopiridol
Item number: TGM-T6837-10mg
Description: Flavopiridol (Alvocidib) (Alvocidib) competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM. It is 7.5-fold more selective for CDK1, 2, 4, 6 versus CDK7. Flavopiridol is initially found to inhibit EGFR and PKA. Phase 1/2. Target: CDK, HIV Protease, Apoptosis,...
| Keywords: | HMR-1275, L868275, Alvocidib, NSC 649890 HCl |
| Application: | Targets cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23] (CDK1, CDC2) |
| CAS | 146426-40-6 |
| MW: | 401.84 D |
From 34.00€
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6-(Dimethylamino)purine
Item number: TGM-T7444-100mg
Description: 6-(Dimethylamino)purine (N,N-Dimethyladenine) is a serine threonine protein kinase and CDK inhibitor. Target: Serine/threonin kinase, CDK. Smiles: CN(C)c1ncnc2nc[nH]c12. References: Nakashima M , Cui Z G , Tabuchi Y , et al. Apoptosis induced by an alkylated purine, 6-dimethylaminopurine, and changes...
| Keywords: | N,N-Dimethyladenine |
| Application: | Protein kinase inhibitor |
| CAS | 938-55-6 |
| MW: | 163.18 D |
30.00€
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ALSTERPAULLONE
Item number: TGM-T7426-100mg
Description: Alsterpaullone is a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells Through Apoptosis-Inducing Effec. Target: CDK, GSK-3, Apoptosis. Smiles: [O-][N+](=O)c1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1. References: Cui C , Wang Y , Wang Y , et al. Alsterpaullone, a Cyclin-Dependent Kinase...
| Application: | CDK inhibitor |
| CAS | 237430-03-4 |
| MW: | 293.28 D |
From 54.00€
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