148 products were found matching "K01370"!

Recognizes endogenous full-length and activated (p20 fragment) mouse caspase-1. Caspase-1 is the best-described inflammatory caspase. It processes the cytokines interleukin-1beta (IL-1beta) and IL-18 and induces pyroptotic cell death. Caspase-1 is activated by multiprotein complexes called Inflammasomes in response...

Recognizes endogenous full-length and activated (p20 fragment) human caspase-1. Caspase-1 is activated by multiprotein complexes called Inflammasomes in response to numerous stimuli that are detected through distinct inflammasomes. NLRC4 responds to cytosolic Caspase-1 is the best-described inflammatory caspase. It...

Kit includes 660-YVAD-FMK red caspase-1 probe, 10x Apoptosis Wash Buffer, Fixative, Technical Protocol. The red FLICA® 660-YVAD-FMK caspase-1 detection probe is comprised of the preferred affinity peptide sequence for active caspase-1 (YVAD), a far-red fluorescent 660 dye label, and a fluoromethyl ketone (FMK)...

This kits makes use of a cell-permeant green fluorecent probe (FAM-YVAD-FMK) that binds to active caspase-1 in living cells undergoing apoptosis. Excitation wavelength 488-492nm, emission 515-535nm.

This kits makes use of a cell-permeant green fluorecent probe (FAM-YVAD-FMK) that binds to active caspase-1 in living cells undergoing apoptosis. Excitation wavelength 488-492nm, emission 515-535nm.

Emricasan is a pan-caspase inhibitor. Ex vivo, emricasan (10 mg/kg) prevents cold ischemia-warm reperfusion-induced sinusoidal endothelial cell (SEC) apoptosis and inhibits caspase-3 activation in rat liver by 55 and 94%, respectively. In vivo, emricasan reduces alanine aminotransferase (ALT) levels (ED50s = 95%....

Description: Emricasan (IDN-6556) is a pan-caspase inhibitor with irreversible properties. Emricasan has anti-inflammatory and anti-apoptotic activity and can be used in the treatment of infections and liver failure, etc. Emricasan also inhibits Zika virus infections. Target: Caspase, Influenza Virus. Smiles:...

Description: Belnacasan (VX-765) is an orally active inhibitor of IL-converting enzyme/caspase-1. Target: Caspase. Smiles: CCO[C@@H]1OC(=O)C[C@@H]1NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)c1ccc(N)c(Cl)c1)C(C)(C)C. References: Wannamaker W, et al....

Description: Nivocasan, also known as GS-9450 and LB-84451, a novel caspase-inhibitor has demonstrated hepatoprotective activity in fibrosis/apoptosis animal models. GS-9450 treatment induced significant reductions in ALT levels in NASH patients. Target: Others. Smiles:...

Description: Ac-YVAD-AFC is a fluorometric peptide substrate of caspase-1, featuring an excitation wavelength (lambda excitation) of 400 nm and an emission wavelength (lambda emission) of 505 nm [1] [2]. Smiles:...

Description: Caspase-1 Protein, Human, Recombinant (HA) is expressed in E. coli expression system with C-HA tag. The predicted molecular weight is 11.4 kDa and the accession number is P29466.

Description: L 709049 is a biologically active compound that is a selective inhibitor of interleukin-1beta converting enzyme (Caspase-1). Caspase inhibitors interfere with the initiation of apoptosis and have multiple clinical applications. Smiles:...