48 products were found matching "K00914"!
No results were found for the filter!
SB-02024
Item number: Cay41231-1
SB-02024 is an inhibitor of vacuolar protein sorting 34 (VPS34, IC50 = 5 nM). It selectively binds to VPS34 (Kd = 0.0011 µM) over eight other PI3K kinases (Kds = 1.2693->30 µM), mTOR (Kd = 1.0199 µM), a panel of 468 kinases at 1 µM, and an additional panel of 97 kinases at 1 µM. SB-02024 (0.7 µM) inhibits autophagic...
| Keywords: | 4-[(3R)-3-methyl-4-morpholinyl]-6-[(2R)-2-(trifluoromethyl)-1-piperidinyl]-2(1H)-pyridinone |
| Application: | VPS34 inhibitor |
| CAS | 2126737-28-6 |
| MW: | 345.4 D |
From 153.00€
*
Autophinib
Item number: TGM-T4219-100mg
Description: Autophinib is a potent autophagy inhibitor with a novel chemotype with IC50 values of 90 and 40 nM for autophagy in starvation induced autophagy assay and rapamycin induced autophagy assay. Target: Autophagy, PI3K. Smiles: Cc1cc(Nc2cc(Cl)nc(Oc3ccc(cc3)[N+]([O-])=O)n2)n[nH]1. References: Robke L, et al....
| Application: | VPS34 inhibitor |
| CAS | 1644443-47-9 |
| MW: | 346.73 D |
From 33.00€
*
Vps34-IN-1
Item number: TGM-T7015-100mg
Description: Vps34-IN-1 (VPS34-IN1) is a potent and highly selective Vps34 inhibitor with IC50 of 25 nM in vitro, which does not significantly inhibit the isoforms of class I as well as class II PI3Ks. Target: PI3K, Autophagy. Smiles: CC(C)(O)CNc1ncc(c(CC2CC2)n1)-c1ccnc(Nc2ccnc(Cl)c2)n1. References: Bago R, et al....
| Keywords: | VPS34-IN1 |
| Application: | Phosphatidylinositol 3-kinase inhibitor |
| CAS | 1383716-33-3 |
| MW: | 425.91 D |
From 40.00€
*
Vps34-PIK-III
Item number: TGM-T6945-100mg
Description: Vps34-PIK-III (VPS34-IN2), a selective inhibitor of VPS34 enzymatic activity, inhibits autophagy and results in the stabilization of autophagy substrates. Target: PI3K, Autophagy. Smiles: Nc1ncc(c(CC2CC2)n1)-c1ccnc(Nc2ccncc2)n1. References: Honda A, et al. Potent, Selective, and Orally Bioavailable...
| Keywords: | PIK-III, VPS34-IN2 |
| Application: | VPS34 inhibitor |
| CAS | 1383716-40-2 |
| MW: | 319.36 D |
From 49.00€
*
VPS34 inhibitor 1 (Compound 19, PIK-III analogue)
Item number: TGM-T7944-100mg
Description: VPS34 inhibitor 1 (Compound 19, PIK-III analogue) (PIK-III analogue) is a potent and selective inhibitor of VPS34( IC50 : 15 nM). Target: PI3K. Smiles: CC(C)(O)CNc1ncc(c(CC2CC2)n1)-c1ccnc(Nc2ccncc2)n1. References: Honda A , Harrington E , Cornella-Taracido I , et al. Potent, Selective, and Orally...
| Keywords: | PIK-III analogue |
| Application: | Phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3, VPS34) inhibitor |
| CAS | 1383716-46-8 |
| MW: | 391.47 D |
From 61.00€
*
Safingol hydrochloride
Item number: TGM-T83978-100mg
Description: Safingol hydrochloride (L-threo-dihydrosphingosine hydrochloride) is a specific inhibitor of protein kinase C. It induces autophagy in solid tumor cells and cancer cell death by inhibiting the PKC and PI3-kinase pathways.BIIB 722 Mesylate is a selective sodium-hydrogen exchange inhibitor. Safingol...
| Keywords: | L-threo-dihydrosphingosine hydrochloride, SPC 100270 hydrochloride |
| Application: | Targets classical protein kinase C beta type [EC:2.7.11.13] (PRKCB) |
| CAS | 139755-79-6 |
| MW: | 337.969 D |
From 198.00€
*
NVP-BAG956
Item number: TGM-TQ0313-100mg
Description: NVP-BAG956 is an ATP-competitive PI3K inhibitor with IC50 values of 34 nM for PI3Kdelta, 56 nM for PI3Kalpha, 112 nM for PI3Kgamma, and 444 nM for PI3Kbeta. Target: PI3K. Smiles: Cc1nc2cnc3ccc(cc3c2n1-c1ccc(cc1)C(C)(C)C#N)C#Cc1cccnc1. References: Marone R, et al. Targeting melanoma with dual...
| Keywords: | BAG956 |
| Application: | PDK1 inhibitor, PI3K inhibitor |
| CAS | 853910-02-8 |
| MW: | 427.5 D |
From 747.00€
*
SAR405
Item number: TGM-T12831L-10mg
Description: SAR-405 is a potent and selective PIK3C3/Vps34 inhibitor (IC50:1.2 nM, Kd:1.5 nM) that prevents autophagy and synergizes with MTOR inhibition in tumor cells. SAR405 treatment also inhibits autophagy induced either by starvation or by MTOR (mechanistic target of rapamycin) inhibition. Combining SAR405...
| Application: | PIK3C3 / Vps34 inhibitor |
| CAS | 1523406-39-4 |
| MW: | 443.85 D |
From 50.00€
*
Anti-PIK3C3
Item number: CSB-PA381950.100
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
| Keywords: | Anti-hVps34, Anti-PI3K type 3, Anti-PI3-kinase type 3, Anti-PtdIns-3-kinase type 3, Anti-Phosphoinositide-3-kinase class... |
| Application: | ELISA, WB |
| Host: | Rabbit |
| Species reactivity: | human, mouse, rat, bovine |
From 126.00€
*
Anti-PIK3C3
Item number: CSB-PA909570.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: PIK3C3. Antigen Species: Human
| Keywords: | Anti-hVps34, Anti-PI3K type 3, Anti-PI3-kinase type 3, Anti-PtdIns-3-kinase type 3, Anti-Phosphoinositide-3-kinase class... |
| Application: | ELISA, IHC |
| Host: | Rabbit |
| Species reactivity: | human, mouse, rat |
From 167.00€
*
Vps34-IN1
Item number: Cay17392-1
Vps34-IN1 is a potent inhibitor of the class III phosphoinositide 3-kinase (PI3K) vacuolar protein sorting 34 (Vps34, IC50 = 25 nM in vitro). It does not significantly inhibit the activity of over 340 additional kinases, including class I and II PI3Ks. Vps34-IN1 dose-dependently inhibits generation of PtdIns-(3)-p,...
| Keywords: | Vacuolar Protein Sorting 34 Inhibitor 1, Vps34 Inhibitor 1,... |
| Application: | Phosphatidylinositol 3-kinase inhibitor |
| CAS | 1383716-33-3 |
| MW: | 425.9 D |
From 35.00€
*
SAR405
Item number: Cay16979-1
SAR405 is an inhibitor of the phosphoinositide 3-kinase (PI3K) class III isoform Vps34 (IC50 = 1.2 nM). It is without effect (IC50 > 10,000 nM) on other PI3K isoforms and mTOR. SAR405 alters vesicle trafficking and inhibits autophagy by blocking autophagosome formation. SAR405 also synergizes with the mTOR inhibitor...
| Keywords: | (8S)-9-[(5-chloro-3-pyridinyl)methyl]-6,7,8,9-tetrahydro-2-[(3R)-3-methyl-4-morpholinyl]-8-(trifluoromethyl)-4H-pyrimido[1... |
| Application: | PIK3C3 / Vps34 inhibitor |
| CAS | 1523406-39-4 |
| MW: | 443.9 D |
From 63.00€
*