47 products were found matching "K00637"!
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K-604 (hydrochloride)
Item number: Cay41119-1
K-604 is an inhibitor of acyl-coenzyme A:cholesterol acyltransferase-1 (ACAT-1, IC50 = 0.45 µM). It is selective for ACAT-1 over ACAT-2 (IC50 = 102.85 µM). K-604 reduces foaming of J774 macrophages (IC50 = 0.026 µM) and reduces cholesterol esterification in monocyte-derived macrophages (IC50 = 0.068 µM). It...
| Keywords: | 4-[2-(1H-benzimidazol-2-ylthio)ethyl]-N-[6-methyl-2,4-bis(methylthio)-3-pyridinyl]-1-piperazineacetamide, dihydrochloride |
| Application: | ACAT-1 inhibitor |
| CAS | 217094-32-1 |
| MW: | 575.6 D |
From 48.00€
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Lecimibide
Item number: TGM-T25651-100mg
Description: Lecimibide (DuP 128) is a potent and selective inhibitor of acyl coenzyme A:cholesterol acyltransferase (ACAT), useful for studying high-lipid-related diseases. Target: Acyltransferase. Smiles: S(CCCCCN(C(NC1=C(F)C=C(F)C=C1)=O)CCCCCCC)C=2NC(=C(N2)C3=CC=CC=C3)C4=CC=CC=C4. References: Wilcox LJ, et al....
| Keywords: | DuP 128, DuP128, DuP-128 |
| Application: | Targets sterol O-acyltransferase [EC:2.3.1.26] (SOAT) |
| CAS | 130804-35-2 |
| MW: | 590.77 D |
From 143.00€
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Enniatin B
Item number: TGM-T13679-1mg
Description: Enniatins B decreases the activation of ERK (p44/p42). Enniatin B is a Fusarium mycotoxin. Enniatin B inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC50 of 113 µM in an enzyme assay using rat liver microsomes. Target: ERK. Smiles:...
| Application: | Ionophore, Apoptosis inducer |
| CAS | 917-13-5 |
| MW: | 639.831 D |
From 644.00€
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Melinamide
Item number: TGM-T16036-10mg
Description: Melinamide is an amide derivative of an unsaturated long-chain fatty acid and also is an inhibitor of cholesterol absorption (IC50: 20.9 µM). Target: Others. Smiles: CCCCC\C=C/C\C=C/CCCCCCCC(=O)NC(C)c1ccccc1. References: Kusunoki J, et al. Effect of F-1394, a potent and selective inhibitor of...
| Keywords: | DL-N-(alpha-Methylbenzyl)linoleamide, AC 223 |
| Application: | Targets sterol O-acyltransferase [EC:2.3.1.26] (SOAT) |
| CAS | 14417-88-0 |
| MW: | 383.61 D |
From 93.00€
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TMP-153
Item number: TGM-T36126-10mg
Description: TMP-153 is a novel and potent ACAT inhibitor with an IC50 value of 5-10 nM for intestinal and hepatic ACAT in animals.TMP-153 has a hypocholesterolemic effect, inhibiting cholesterol uptake and lowering plasma cholesterol in rats and hamsters. Target: Acyltransferase. Smiles:...
| Application: | ACAT inhibitor |
| CAS | 128831-46-9 |
| MW: | 437.87 D |
From 286.00€
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Terpendole I
Item number: TGM-T36329-1mg
Description: Terpendole I is a fungal metabolite that has been found in A. yamanashiensis.1 It is a weak inhibitor of acyl-coenzyme A:cholesterol acyltransferase (ACAT, IC50 = 145 µM) and is active against the bacteria B. cereus and B. subtilis (MICs = 100 µg/ml for both) but not S. aureus, P. aeruginosa, or K....
| Application: | Fungal metabolite, weak ACAT inhibitor |
| CAS | 167612-17-1 |
| MW: | 453.579 D |
375.00€
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Avasimibe
Item number: TGM-T2753-100mg
Description: Avasimibe (PD-148515) is an orally bioavailable inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT, IC50: 3.3 µM) that prevents cholesterol deposition in the arterial wall. It also inhibits human P450 isoenzymes CYP2C9/1A2/2C19 (IC50: 2.9/13.9/26.5 µM). Target: Acyltransferase, P450....
| Keywords: | CI-1011, PD-148515 |
| Application: | Targets sterol O-acyltransferase [EC:2.3.1.26] (SOAT) |
| CAS | 166518-60-1 |
| MW: | 501.72 D |
From 43.00€
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Oleic Acid-2,6-diisopropylanilide
Item number: TGM-T35603-10mg
Description: Oleic acid-2,6-diisopropylanilide is an inhibitor of acylCoA:cholesterol acyltransferase (ACAT), an intracellular cholesteryl ester synthase involved in dietary cholesterol absorption, with an IC50 of 7 nM. When administered at 0.05% to rabbits or rats on a high fat, high cholesterol diet, it reduces...
| Application: | acylCoA inhibitor |
| CAS | 140112-65-8 |
| MW: | 441.744 D |
From 83.00€
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CAY10485
Item number: TGM-T35984-100mg
Description: Acyl-coenzyme A: cholesterol acyltransferase-1 and -2 (ACAT-1 and ACAT-2) catalyze the formation of cholesterol esters from cholesterol and long chain fatty acyl-coenzyme A, and may play a role in the development of atherosclerosis. CAY10485 inhibits human ACAT-1 and ACAT-2 with an IC50 values of 95 and...
| Application: | acylCoA inhibitor |
| CAS | 615264-62-5 |
| MW: | 477.51 D |
From 86.00€
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CAY10486
Item number: TGM-T36549-10mg
Description: Acyl-Coenzyme A: cholesterol acyltransferase-1 and -2 (ACAT-1 and ACAT-2) catalyze the formation of cholesterol esters from cholesterol and long chain fatty acyl-coenzyme A, and may play a role in the development of atherosclerosis. CAY10486 inhibits human ACAT-1 and ACAT-2 equally with an IC50 value of...
| Application: | ACAT-1 / ACAT-2 inhibitor |
| CAS | 615264-52-3 |
| MW: | 325.36 D |
From 74.00€
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Phenylpyropene A
Item number: TGM-T37690-1mg
Description: Phenylpyropene A is a fungal metabolite originally isolated from P. griseofulvum that has enzyme inhibitory and insecticidal activities.1,2,3 It inhibits acyl-coenzyme A:cholesterol acyltransferase (ACAT, IC50 = 0.8 µM).1 Phenylpyropene A inhibits diacylglycerol acyltransferase (DGAT) in rat liver...
| Application: | Fungal metabolite, ACAT inhibitor |
| CAS | 189564-20-3 |
| MW: | 582.64 D |
From 340.00€
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Enniatin B
Item number: Cay15382-1
Enniatins are cyclichexadepsipeptides commonly isolated from fungi. Many act as ionophores, forming pores in cellular membranes to allow selective ion transport. Enniatin B is a relatively poor ionophore with some capacity to facilitate import of K+ and Na+ across membranes. It inhibits the pleiotropic drug...
| Keywords: | Antibiotic 86/88,... |
| Application: | Ionophore, Apoptosis inducer |
| CAS | 917-13-5 |
| MW: | 639.8 D |
From 204.00€
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