80 products were found matching "K00560"!
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Capecitabine
Item number: TGM-T1408-1g
Description: Capecitabine (Capecitibine) is a fluoropyrimidine carbamate belonging to the class of antineoplastic agents called antimetabolites. As a prodrug, capecitabine is selectively activated by tumor cells to its cytotoxic moiety, 5-fluorouracil (5-FU), subsequently, 5-FU is metabolized to two active...
| Keywords: | Capiibine, RO 09-1978, Capecitibine, Xeloda |
| Application: | Targets thymidylate synthase [EC:2.1.1.45] (thyA, TYMS) |
| CAS | 154361-50-9 |
| MW: | 359.35 D |
From 48.00€
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Tegafur
Item number: TGM-T1378-100mg
Description: Tegafur (FT 207) is a congener of the antimetabolite fluorouracil with antineoplastic activity. Tegafur is a prodrug that is gradually converted to fluorouracil in the liver by the cytochrome P-450 enzyme. Target: DNA/RNA Synthesis, Nucleoside Antimetabolite/Analog. Smiles: O=C1N(C=C(F)C(=O)N1)C2CCCO2....
| Keywords: | FT 207, NSC 148958, FT-207, Fluorafur |
| Application: | Targets thymidylate synthase [EC:2.1.1.45] (thyA, TYMS) |
| CAS | 17902-23-7 |
| MW: | 200.17 D |
From 39.00€
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Trifluridine
Item number: TGM-T1428-100mg
Description: Trifluridine (NSC-75520) is a fluorinated thymidine analog with potential antineoplastic activity. Trifluridine is incorporated into DNA and inhibits thymidylate synthase, resulting in inhibition of DNA synthesis, inhibition of protein synthesis, and apoptosis. This agent also exhibits antiviral...
| Keywords: | Trifluorothymidine, 5-Trifluorothymidine, NSC 75520, NSC 529182, Trifluridina, Viroptic |
| Application: | Targets thymidylate synthase [EC:2.1.1.45] (thyA, TYMS) |
| CAS | 70-00-8 |
| MW: | 296.2 D |
From 33.00€
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Nolatrexed dihydrochloride
Item number: TGM-T2627-10mg
Description: Nolatrexed dihydrochloride (Thymitaq) is the dihydrochloride salt of nolatrexed, a water-soluble lipophilic quinazoline folate analog with antineoplastic activity. Nolatrexed occupies the folate binding site of thymidylate synthase, resulting in inhibition of thymidylate synthase activity and thymine...
| Keywords: | Thymitaq, AG 337 |
| Application: | Thymidylate synthase inhibitor |
| CAS | 152946-68-4 |
| MW: | 357.26 D |
From 41.00€
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(6R,S)-5,6,7,8-Tetrahydrofolic Acid (hydrochloride)
Item number: TGM-T35413-10mg
Description: (6R,S)-5,6,7,8-Tetrahydrofolic acid (THFA), the reduced form of folic acid, serves as a cofactor in methyltransferase reactions and is the major one-carbon carrier in one carbon metabolism. Its metabolites participate in the synthesis of thymidine for incorporation into DNA or the synthesis of purines,...
| Application: | Tetrahydrofolic acid diastereomer |
| CAS | 150731-85-4 |
| MW: | 481.89 D |
From 98.00€
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Fosifloxuridine nafalbenamide
Item number: TGM-T33762-100mg
Description: Fosifloxuridine nafalbenamide (NUC 3373), a pyrimidine nucleotide analogue, is a Thymidylate synthase inhibitor. NUC-3373 has anticancer activity. NUC-3373 is a ProTide transformation of 5-FU that generates much higher concentrations of FUDR-MP in patients' cells. Target: DNA/RNA Synthesis. Smiles:...
| Keywords: | NUC-3373, NUC3373, NUC 3373 |
| Application: | Targets thymidylate synthase [EC:2.1.1.45] (thyA, TYMS) |
| CAS | 1332837-31-6 |
| MW: | 613.53 D |
From 83.00€
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Vanoxonin
Item number: TGM-T26315-25mg
Description: Vanoxonin is a new thymidylate synthetase inhibitor. Target: Others. Smiles: C(N[C@H](C(N[C@@H](CCCN(C(C)=O)O)C(O)=O)=O)[C@@H](C)O)(=O)C1=C(O)C(O)=CC=C1. References: Kanai F, Isshiki K, Umezawa Y, Morishima H, Naganawa H, Takita T, Takeuchi T, Umezawa H. Vanoxonin, a new inhibitor of thymidylate...
| Keywords: | MG-245-CF2-A, Antibiotic MG 245CF2A |
| Application: | Bioctive bacterial metabolite |
| CAS | 86933-99-5 |
| MW: | 427.41 D |
From 2,272.00€
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Arfolitixorin
Item number: TGM-T26654-25mg
Description: Arfolitixorin is an antifolate modulator. Target: Others. Smiles: O=C1C=2N3[C@@](CN(C3)C4=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C4)(CNC2NC(N)=N1)[H]
| Application: | Targets thymidylate synthase [EC:2.1.1.45] (thyA, TYMS) |
| CAS | 31690-11-6 |
| MW: | 457.44 D |
From 1,521.00€
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5,6-dihydro-5-Fluorouracil
Item number: TGM-T36870-10mg
Description: 5,6-dihydro-5-Fluorouracil (5-FUH2) is an inactive metabolite of 5-FU and can be used for the study of organismal metabolism. Target: Others. Smiles: FC1CNC(=O)NC1=O. References: McQuade RM, et al. Gastrointestinal dysfunction and enteric neurotoxicity following treatment with anticancer...
| Keywords: | 5-fluorodihydrouracil, 5-Fluoro-dihydro-pyrimidine-2,4-dione |
| Application: | Apoptosis inducer |
| CAS | 696-06-0 |
| MW: | 132.09 D |
From 226.00€
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5-Fluorouracil-13C,15N2
Item number: TGM-T36895-1mg
Description: 5-Fluorouracil-13C,15N2 is intended for use as an internal standard for the quantification of 5-flurouracil by GC- or LC-MS. 5-Fluorouracil is a pyrimidine analog that irreversibly inhibits thymidylate synthase, blocking the synthesis of thymidine which is required for DNA synthesis. Intracellular...
| Keywords: | 5-Fluorouracil-13C,15N2 |
| Application: | GC-MS, LC-MS, quantification, internal standard, thymidylate synthase inhibitor |
| CAS | 1189423-58-2 |
| MW: | 133.057 D |
854.00€
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5-Fluorouracil
Item number: Cay14416-5
5-Fluorouracil (5-FU) is a prodrug form of the thymidylate synthase inhibitor fluorodeoxyuridylate (FdUMP). It is also converted to the active metabolites FUTP and FdUTP, which induce RNA and DNA damage, respectively. In vivo, 5-FU (15 mg/kg) when administered in combination with docetaxel (Cay-11637) reduces tumor...
| Keywords: | 5-FU, NSC 19893, Ro 2-9757, U-8953, 5-fluoro-2,4(1H,3H)-pyrimidinedione |
| Application: | Apoptosis inducer, Thymidylate synthase inhibitor |
| CAS | 51-21-8 |
| MW: | 130.1 D |
From 45.00€
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Anti-Thymidylate Synthase (TS), human
Item number: 100-401-199
This antiserum is directed against human Thymidylate Synthase and is useful in determining its presence in various assays. Because inhibition of Thymidylate Synthase prevents DNA synthesis and cell proliferation, the enzyme is an important target for cancer chemotherapeutic drugs, specifically the fluoropyrimidine...
| Keywords: | Anti-TS, Anti-TYMS, Anti-TSase, EC=2.1.1.45, Anti-Thymidylate synthase |
| Application: | ELISA, IHC, WB |
| Host: | Rabbit |
| Species reactivity: | human |
719.00€
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