99 products were found matching "K00558"!
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GSK3685032
Item number: LKT-G733404.1
GSK3685032 is an inhibitor of DNA methyltransferase 1. SMILES: CCC1=C(C(=NC(=C1C#N)SC(C2=CC=CC=C2)C(=O)N)N3CCC(CC3)N)C#N
| Keywords: | GSK-3685032, 2-[6-(4-aminopiperidin-1-yl)-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide |
| Application: | Reversible DNMT1-selective inhibitor |
| CAS | 2170137-61-6 |
| MW: | 420.54 D |
From 84.00€
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5-Azacytidine
Item number: Cay11164-50
5-Azacytidine, a chemical analogue of the DNA and RNA nucleoside cytidine, is an inhibitor of DNA methyltransferases, potentially serving to reverse epigenetic changes. It reduces hypermethylation associated with certain diseases, including myelodysplastic syndromes (IC50s = 2.4 and 2.6 µM for in vitro anti-myeloma...
| Keywords: | 5-AzaC, Antibiotic U 18496, Ladakamycin, Mylosar, NSC 102816, NSC 103-627, U 18496, WR 183027,... |
| Application: | DNA methyltransferase inhibitor |
| CAS | 320-67-2 |
| MW: | 244.2 D |
From 28.00€
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Decitabine
Item number: Cay11166-5
5-Azacytidine is an analog of cytidine which can be incorporated into DNA, inhibit DNA methyltransferases, and cause hypomethylation of cytosine residues in the absence of any significant mutagenic effects. Decitabine is a 2'-deoxy analog of 5-azacytidine which similarly causes hypomethylation of DNA by inhibiting...
| Keywords: | 5-aza-2'-Deoxycytidine, DAC, NSC 127716, 4-amino-1-(2-deoxy-beta-D-erythro-pentofuranosyl)-1,3,5-triazin-2(1H)-one |
| Application: | Cytidine analog |
| CAS | 2353-33-5 |
| MW: | 228.2 D |
From 65.00€
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SW155246
Item number: TGM-T8967-100mg
Description: SW155246 is a potent and selective inhibitor of DNMT1 (DNA methyltransferase 1, IC50 of 1.2 µM). SW155246 induces re-expression of the tumor suppressor geneRASSF1 in A549 cells. Target: DNA Methyltransferase. Smiles: Oc1ccc(NS(=O)(=O)c2ccc(Cl)c(c2)[N+]([O-])=O)c2ccccc12. References: Medina-Franco J , O...
| Application: | DNMT1 antagonist |
| CAS | 420092-79-1 |
| MW: | 378.79 D |
From 42.00€
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SGI-1027
Item number: TGM-T1904-100mg
Description: SGI-1027 (DNA Methyltransferase Inhibitor II) is an effective and selective inhibitor of DNA methyltransferase (DNMT). The IC50 of SGI-1027(SGI1027) against DNMT1, DNMT3A, and DNMT3B are 6, 8, 7.5 µM, respectively. Target: DNA Methyltransferase, Apoptosis. Smiles:...
| Keywords: | SGI1027, DNA Methyltransferase Inhibitor II |
| Application: | DNMT1 / DNMT3A / DNMT3B inhibitor |
| CAS | 1020149-73-8 |
| MW: | 461.52 D |
From 54.00€
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RX-3117
Item number: TGM-T16813-100mg
Description: RX-3117 (fluorocyclopentenylcytosine) is a novel a cytidine analog. RX-3117 displays anticancer activity in several cancer cell lines, including gemcitabine-resistant variants. Target: Nucleoside Antimetabolite/Analog. Smiles: Nc1ccn([C@H]2[C@H](O)[C@H](O)C(CO)=C2F)c(=O)n1. References: Peters GJ, et al....
| Keywords: | fluorocyclopentenylcytosine, TV-1360 |
| Application: | Targets DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37] (DNMT1, dcm) |
| CAS | 865838-26-2 |
| MW: | 257.22 D |
From 159.00€
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DC-05
Item number: TGM-T15080-100mg
Description: DC-05 is an inhibitor of DNA methyltransferase 1 (DNMT1) (IC50 and a Kd: 10.3 µM and 1.09 µM, respectively). Target: Histone Methyltransferase, DNA Methyltransferase. Smiles: OC(CNCCc1c[nH]c2ccccc12)Cn1c2ccccc2c2ccccc12. References: Chen S, et al. Identifying novel selective non-nucleoside DNA...
| Application: | Non-nucleoside DNMT1 inhibitor |
| CAS | 890643-16-0 |
| MW: | 383.49 D |
From 131.00€
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RG108
Item number: TGM-T2038-100mg
Description: RG108 (N-Phthalyl-L-tryptophan) is a DNA methyltransferase inhibitor with an IC50 of 115 nM. Target: DNA Methyltransferase. Smiles: [C@H](CC=1C=2C(NC1)=CC=CC2)(C(O)=O)N3C(=O)C=4C(C3=O)=CC=CC4. References: Brueckner B, et al, Cancer Res, 2005, 65(14), 6305-6311.
| Keywords: | N-Phthalyl-L-tryptophan |
| Application: | DNA methyltransferase inhibitor |
| CAS | 48208-26-0 |
| MW: | 334.33 D |
From 40.00€
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OM173-alphaA
Item number: TGM-T69058-1mg
Description: OM173-alphaA is a quinone bacterial metabolite that inhibits the growth of the bacteria M. gallisepticum, M. pneumoniae, and S. aureus. OM173-alphaA also inhibits the growth of the plant pathogenic fungus P. oryzae and several species of Trichophyton. Target: Others. Smiles:...
| Application: | Antibiotic, DNMT3B inhibitor |
| CAS | 58286-56-9 |
| MW: | 316.31 D |
From 243.00€
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Anti-DNMT1
Item number: CSB-PA106123.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: DNMT1. Antigen Species: Human
| Keywords: | Anti-AIM, Anti-MCMT, Anti-DNMT1, Anti-Dnmt1, Anti-M.HsaI, EC=2.1.1.37, Anti-DNA MTase HsaI, Anti-DNA methyltransferase... |
| Application: | ELISA, IHC |
| Host: | Rabbit |
| Species reactivity: | human |
From 167.00€
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Anti-DNMT1
Item number: CSB-PA183398.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: DNMT1. Antigen Species: Human
| Keywords: | Anti-AIM, Anti-MCMT, Anti-DNMT1, Anti-Dnmt1, Anti-M.HsaI, EC=2.1.1.37, Anti-DNA MTase HsaI, Anti-DNA methyltransferase... |
| Application: | ELISA, IHC |
| Host: | Rabbit |
| Species reactivity: | human |
From 167.00€
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5-Aza-2'-deoxycytidine (Decitabine)
Item number: LKT-A9603.5
It is a hypomethylating agent. It hypomethylates DNA by inhibiting DNA methyltransferase.
| CAS | 2353-33-5 |
| MW: | 228,21 D |
From 104.00€
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