39 products were found matching "K00541"!

Description: Bisubstrate inhibitor 78 is an inhibitor of nicotinamide N-methyltransferase (NNMT, IC50= 1.41 µM).1It binds the NNMT active site in the binding pockets for the NNMT substrates S-adenosyl-L-methionine (SAM) and nicotinamide . Bisubstrate inhibitor 78 is selective for NNMT over histone-lysine...

Description: TRIA-662 (Nicotinamide Chloromethylate) is a niacin metabolite excreted via the urinary system. Target: Others, Endogenous Metabolite. Smiles: [Cl-].C[n+]1cccc(c1)C(N)=O. References: Zhao J, Zhang Y, Liu Y, et al. Antidepressant-like effects of 1-methylnicotinamide in a chronic unpredictable mild...

Description: N-Methylnicotinamide is one of the endogenous metabolites that ameliorates endothelial dysfunction. Target: Endogenous Metabolite, Others. Smiles: CNC(=O)c1cccnc1. References: Pumpo, R., et al.: Am. J. Gastroenterol., 96, 1183 (2001)

Description: JBSNF-000088 is an Nicotinamide N-methyltransferase (NNMT)inhibitor. It is used for the treatment of metabolic disorders. Target: Others. Smiles: C(N)(=O)C=1C=CC(OC)=NC1. References: Kannt A, Rajagopal S, Kadnur SV, Suresh J, Bhamidipati RK, Swaminathan S, Hallur MS, Kristam R, Elvert R, Czech J,...

Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 1-264aa. Protein Length: Full Length. Tag Info: N-terminal GST-tagged. Target Protein Sequence: MESGFTSKDT YLSHFNPRDY LEKYYKFGSR HSAESQILKH LLKNLFKIFC LDGVKGDLLI DIGSGPTIYQ LLSACESFKE IVVTDYSDQN LQELEKWLKK EPEAFDWSPV VTYVCDLEGN RVKGPEKEEK LRQAVKQVLK...

Nicotinamide is a precursor of NAD (Cay-16077) and NADP (Cay-10004675), which serve essential functions in modulating cellular redox status and controlling signaling and transcriptional events. 1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced by the action of nicotinamide...

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human NNMT. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human NNMT. Next,...

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse NNMT. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse NNMT. Next,...

N-Methylnicotinamide is an isomer of nicotinamide. N-methylnicotinamide (20 mg/animal) increases urinary excretion of nicotinamide, 1-methylnicotinamide (Cay-16604), 1-methyl-2-pyridone-5-carboxamide, and 1-methyl-4-pyridone-3-carboxamide in mice in similar ratios as those excreted following nicotinamide...

JBSNF-000088 is an inhibitor of nicotinamide N-methyltransferase (NNMT, IC50s = 1.8, 2.8, and 5 µM for human, monkey, and mouse NNMT, respectively). It inhibits NNMT and reduces 1-methyl-nicotinamide (MNA) levels in U2OS and 3T3L1 cells (IC50s = 1.6 and 6.3 µM, respectively). JBSNF-000088 (50 mg/kg) reduces visceral...

Nicotinamide N-Methyltransferase (NNMT) methylates nicotinamide and other pyridine containing compounds. NNMT transfers a methyl group from S-adenosylmethionine (SAM) to nitrogen N1 of nicotinamide to produce 1-methylnicotinamide (MNA) and S-adenosylhomocysteine. MNA is a messenger molecule that increases neurite...

Bisubstrate inhibitor 78 is an inhibitor of nicotinamide N-methyltransferase (NNMT, IC50 = 1.41 µM). It binds the NNMT active site in the binding pockets for the NNMT substrates S-adenosyl-L-methionine (SAM) and nicotinamide (Cay-11127). Bisubstrate inhibitor 78 is selective for NNMT over histone-lysine...