173 products were found matching "K00463"!
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IDO-IN-3
Item number: Cay28432-1
IDO-IN-3 is an inhibitor of indoleamine-2,3-dioxygenase 1 (IDO1, IC50s = 290 and 98 nM for the human recombinant enzyme in a cell-free assay and in HeLa cells, respectively).Formal Name: 4-[(2-aminoethyl)amino]-N'-(3-bromo-4-fluorophenyl)-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide. CAS Number: 2070018-30-1....
| Keywords: | 4-[(2-aminoethyl)amino]-N'-(3-bromo-4-fluorophenyl)-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide |
| Application: | IDO-1 inhibitor |
| CAS | 2070018-30-1 |
| MW: | 359.2 D |
From 136.00€
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IDO1 and HDAC1 Inhibitor
Item number: TGM-T11625-25mg
Description: IDO1 and HDAC1 Inhibitor is a dual IDO1 and HDAC1 inhibitor (IC50s: 69.0 nM and 66.5 nM). Target: Others. Smiles: C(=NC1=CC(Br)=C(F)C=C1)(NO)C=2C(NCCNC(=O)C3=CC=C(C(NC4=C(N)C=CC=C4)=O)C=C3)=NON2. References: Fang K, et al. Discovery of Novel Indoleamine 2,3-Dioxygenase 1 (IDO1) and Histone Deacetylase...
| Application: | IDO1 / HDAC1 inhibitor |
| CAS | 2227044-16-6 |
| MW: | 597.4 D |
1,491.00€
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IDO1-IN-5
Item number: TGM-T11901-100mg
Description: IDO1-IN-5 is a selective, potent and brain penetrated inhibitor of IDO1 activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1. Target: Indoleamine 2,3-Dioxygenase (IDO), IDO. Smiles: C[C@@H](NC(=O)c1ccc(F)cc1)c1ccc2N(CCc2c1)C(=O)C1CCOCC1. References: Frank C. Dorsey, et al....
| Application: | IDO1 inhibitor |
| CAS | 2166616-75-5 |
| MW: | 396.45 D |
From 34.00€
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Epacadostat
Item number: TGM-T3548-100mg
Description: Epacadostat (INCB 024360) is an oral-available inhibitor of indoleamine 2, 3-dioxygenase (IDO1), increasing the proliferation and activation of various immune cells and reducing tumor-associated regulatory T cells. Target: Indoleamine 2,3-Dioxygenase (IDO), IDO. Smiles:...
| Keywords: | IDO Inhibitor 1, INCB 024360 |
| Application: | Targets indoleamine 2,3-dioxygenase [EC:1.13.11.52] (IDO, INDO) |
| CAS | 1204669-58-8 |
| MW: | 438.23 D |
From 39.00€
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CAY10763
Item number: TGM-T36645-1mg
Description: CAY10763 is a dual inhibitor of indolamine 2,3-dioxygenase 1 (IDO1, IC50= 46 nM) and STAT3 activation.1It binds to STAT3 (Kd= 530 nM) and selectively reduces the levels of STAT3 phosphorylated at the tyrosine in position 705 (STAT3Y705) over phosphorylated STAT3S727, STAT1, and STAT5 in SKOV3 cells when...
| Keywords: | CAY10763 |
| Application: | IDO1 / STAT3 activation dual inhibitor |
| CAS | 2364458-49-9 |
| MW: | 471.513 D |
From 193.00€
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(S)-Indoximod
Item number: TGM-T3S1967-50mg
Description: (S)-Indoximod (L-Abrine) exhibits inhibition of rabbit small intestine indoleamine 2, 3-dioxygenase, competitive inhibition of IDO, reduction of Foxp3 protein expression in tumor of C57BL/6 mouse allografted with mouse LLC cells at 200 mg/kg, induction of IDO1 protein expression in tumor of C57BL/6...
| Keywords: | L-Abrine, N-ME-Tryptophan, Abrine |
| Application: | IDO inhibitor |
| CAS | 21339-55-9 |
| MW: | 218.25 D |
30.00€
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PF-06840003
Item number: TGM-T4307-100mg
Description: PF-06840003 (EOS200271) is a specific and orally active IDO-1 inhibitor. Target: IDO, Indoleamine 2,3-Dioxygenase (IDO). Smiles: Fc1ccc2[nH]cc(C3CC(=O)NC3=O)c2c1. References: Tumang J, et al. PF-06840003: a highly selective IDO-1 inhibitor that shows good in vivo efficacy in combination with immune...
| Keywords: | EOS200271, PF 06840003 |
| Application: | IDO-1 inhibitor |
| CAS | 198474-05-4 |
| MW: | 232.21 D |
From 38.00€
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PCC0208009
Item number: TGM-T4142-100mg
Description: PCC0208009 (IDO-IN-2) is an IDO inhibitor. Target: Indoleamine 2,3-Dioxygenase (IDO). Smiles: CC(C)CN(CC(C)C)c1ccc(cc1NC(=O)Nc1ccc(C)cc1)-c1ccccc1-c1nn[nH]n1. References: Jay A. Markwalder, et al. US20160200674A1. 2013.
| Keywords: | DO-IN-2, IDO inhibitor 1, IDO-IN-2 |
| Application: | IDO1 inhibitor |
| CAS | 1668565-74-9 |
| MW: | 497.63 D |
From 39.00€
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MMG-0358
Item number: TGM-T71954-10mg
Description: MMG-0358 is a novel potent IDO1 inhibitor, showing low cytotoxicity and higher selectivity for IDO1 over TDO enzyme. Target: Others. Smiles: OC1=C(C=C(Cl)C=C1)C2=CN=NN2
| Application: | IDO1 enzyme activity & inhibition experiments |
| CAS | 1378976-02-3 |
| MW: | 195.61 D |
From 193.00€
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IDO-IN-1
Item number: TGM-T7181-100mg
Description: IDO-IN-1 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor with IC50 values of 59 nM for human IDO enzymatic activity and 12 nM for HeLa cell assays. Target: Indoleamine 2,3-Dioxygenase (IDO). Smiles: Nc1nonc1\C(Nc1ccc(F)c(Br)c1)=N\O. References: Discovery of Potent Competitive Inhibitors of...
| Application: | Indoleamine-2,3-dioxygenase (IDO) inhibitor |
| CAS | 914638-30-5 |
| MW: | 316.09 D |
From 78.00€
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IDO inhibitor 1
Item number: TGM-T7660-100mg
Description: IDO inhibitor 1 is an potent inhibitor of indoleamine-2,3 dioxygenase (IDO) ( IC50 <100 nM).with potential immunomodulating and antineoplastic activities. Target: Indoleamine 2,3-Dioxygenase (IDO). Smiles: NS(=O)(=O)NCCNc1nonc1/C(=N/O)Nc1ccc(F)c(Br)c1. References: Devaraja K . Current Prospects of...
| Application: | IDO inhibitor |
| CAS | 1204669-37-3 |
| MW: | 438.23 D |
From 89.00€
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CAY10581
Item number: TGM-T73351-10mg
Description: CAY10581, a derivative of pyranonaphthoquinone, serves as a highly specific and reversible uncompetitive inhibitor of IDO, demonstrating potency with an IC50 value of 55 nM. Target: Others. Smiles: N(CC1=CC=CC=C1)[C@H]2C3=C(C(=O)C=4C(C3=O)=CC=CC4)OC(C)(C)[C@H]2O
| Application: | Indoleamine 2,3-dioxygenase inhibitor |
| CAS | 1018340-07-2 |
| MW: | 363.41 D |
From 91.00€
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