126 products were found matching "K00461"!
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Zileuton
Item number: Cay10006967-50
Zileuton is a reversible 5-lipoxygenase (5-LO) inhibitor. It inhibits 5-LO activity in rat basophilic leukemia-1 (RBL-1) cell supernatant with an IC50 value of 0.5 µM. Zileuton inhibits leukotriene B4 (LTB4, Cay-20110) production induced by the calcium ionophore A23187 (Cay-11016) in purified human peripheral blood...
| Keywords: | A 64077, N-(1-benzo[b]thien-2-ylethyl)-N-hydroxy-urea |
| Application: | 5-LO inhibitor |
| CAS | 111406-87-2 |
| MW: | 236.3 D |
From 29.00€
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Lipoxygenin
Item number: TGM-T35541-10mg
Description: Lipoxygenin is an inhibitor of 5-lipoxygenase (5-LO) with an IC50value of 5 µM for inhibition of 5-LO product synthesis in isolated human granulocytes stimulated with the cation ionophore A23187 .1It inhibits hedgehog-dependent signaling in Shh-LIGHT2 cells and TGF-beta-, activin A-, bone morphogenic...
| Application: | 5-LO inhibitor |
| CAS | 2247911-68-6 |
| MW: | 402.44 D |
From 108.00€
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Setileuton
Item number: TGM-T34624-100mg
Description: Setileuton (MK0633) is a specific 5-LOX inhibitor and can be used in research on asthma and atherosclerosis. Target: Lipoxygenase. Smiles: O=C1C=C(C=2C(=CC(CNC=3OC([C@](C(F)(F)F)(CC)O)=NN3)=CC2)O1)C4=CC=C(F)C=C4. References: Maciolek CM, et al. Novel cytochrome P450-mediated ring opening of the...
| Keywords: | MK 0633, MK-0633, MK0633 |
| Application: | Targets arachidonate 5-lipoxygenase [EC:1.13.11.34] (ALOX5) |
| CAS | 910656-27-8 |
| MW: | 463.38 D |
From 195.00€
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Myxochelin A
Item number: TGM-T35692-1mg
Description: Myxochelin A is a microbial metabolite found in *A. disciformis* with diverse biological activities. It exhibits activity against Gram-positive bacteria, including *B. cereus*, *S. aureus*, and *M. luteus*, but not against Gram-negative bacteria or fungi at a concentration of 80 µg/disc in an agar...
| Application: | 5-lipoxygenase inhibitor |
| CAS | 120243-02-9 |
| MW: | 404.419 D |
959.00€
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Esculetin
Item number: TGM-T2798-100mg
Description: Esculetin (Cichorigenin) is a coumarin derivative from various natural plant products with various biological and pharmaceutical properties including anti-edema, anti-inflammatory and anti-tumour effects. It inhibits lipoxygenases (LOs). Target: Akt, Lipoxygenase, PI3K. Smiles:...
| Keywords: | Aesculetin, Cichorigenin |
| Application: | Iron chelator, iron-containing enzyme inhibitor, apoptosis inducer, antioxidant |
| CAS | 305-01-1 |
| MW: | 178.14 D |
From 45.00€
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Eupatilin
Item number: TGM-T3362-100mg
Description: Eupatilin (NSC-122413), a flavone derived from Artemisia princepsPampanini, is a PPARalpha agonist, with pharmacological activity. Target: PPAR, Autophagy. Smiles: COc1ccc(cc1OC)-c1cc(=O)c2c(O)c(OC)c(O)cc2o1. References: Li YY, et al. Oncol Lett. 2015 Oct,10(4):2505-2510.,
| Keywords: | NSC 122413 |
| Application: | Selective 5-lipoxygenase inhibitor |
| CAS | 22368-21-4 |
| MW: | 344.32 D |
From 31.00€
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Fenleuton
Item number: TGM-T27311-25mg
Description: Fenleuton is a 5-lipoxygenase inhibitor. Target: Others. Smiles: O(C1=CC(C#CC(N(C(N)=O)O)C)=CC=C1)C2=CC=C(F)C=C2. References: Marr KA, Lees P, Page CP, Cunningham FM. Effect of the 5-lipoxygenase inhibitor, fenleuton, on antigen-induced neutrophil accumulation and lung function changes in horses with...
| Keywords: | A76745, A 767456, A-76745 |
| Application: | Targets arachidonate 5-lipoxygenase [EC:1.13.11.34] (ALOX5) |
| CAS | 141579-54-6 |
| MW: | 314.31 D |
From 1,520.00€
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Enazadrem phosphate
Item number: TGM-T31622-25mg
Description: Enazadrem phosphate is a bio-active chemical. Detailed information has not been published. Target: Others. Smiles: O=P(O)(O)O.OC=1C(=NC(=NC1C)NCCCCCCC=2C=CC=CC2)C
| Keywords: | SCHEMBL219332, UNII-93VML10KA9, Enazadrem phosphate (USAN) |
| Application: | Targets arachidonate 5-lipoxygenase [EC:1.13.11.34] (ALOX5) |
| CAS | 132956-22-0 |
| MW: | 397.41 D |
1,520.00€
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CAY10606
Item number: TGM-T37353-1mg
Description: CAY10606 has a wide range of applications in life science related research. Target: Others. Smiles: CCOC(=O)c1c(Cc2cccc(Cl)c2)[nH]c2c1cc(O)c1ccccc21
| Application: | 5-LO inhibitor |
| CAS | 1159576-98-3 |
| MW: | 379.84 D |
From 154.00€
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AKBA
Item number: TGM-T5S1569-100mg
Description: AKBA (3-O-Acetyl-11-keto-beta-boswellic acid), a natural component from frankincense, is a novel activator of Nrf2. Target: Endogenous Metabolite, Reactive Oxygen Species, HIF/HIF Prolyl-Hydroxylase, Others. Smiles: CC1CCC2(C)CCC3(C)C(=CC(=O)C4C5(C)CCC(OC(C)=O)C(C)(C5CCC34C)C(O)=O)C2C1C. References:...
| Keywords: | 3-O-Acetyl-11-keto-beta-boswellic acid, 3-O-Acetyl-11-keto-beta-boswellic acid, Acetyl-11-keto-beta-boswellic acid |
| Application: | 5-lipoxygenase inhibitor |
| CAS | 67416-61-9 |
| MW: | 512.72 D |
From 37.00€
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Piriprost
Item number: TGM-T68682-100mg
Description: Piriprost is a leukotriene inhibitor attenuates the smoke-induced increase in alveolar-capillary barrier permeability and decrease in plasminogen activator activity and causes a swelling of type I alveolar epithelium. Target: Others. Smiles:...
| Application: | Targets arachidonate 5-lipoxygenase [EC:1.13.11.34] (ALOX5) |
| CAS | 79672-88-1 |
| MW: | 425.56 D |
From 1,520.00€
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MK-886 sodium salt
Item number: TGM-T71309-10mg
Description: MK-886 sodium salt inhibits leukotriene biosynthesis in leukocytes. Target: Others
| Application: | Leukotriene biosynthesis inhibitor |
| CAS | 118427-55-7 |
| MW: | 494.06 D |
From 77.00€
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