58 products were found matching "K00287"!
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Cycloguanil hydrochloride
Item number: TGM-T5420-100mg
Description: Cycloguanil hydrochloride (Chloroguanide Triazine) is an active metabolite of the antimalarial compound proguanil. It acts as an inhibitor of dihydrofolate reductase (Kis: 0.3 and 1.5 nM for Plasmodium and human forms, respectively). Target: Parasite, Drug Metabolite. Smiles:...
| Keywords: | Chloroguanide Triazine |
| Application: | DHFR inhibitor |
| CAS | 152-53-4 |
| MW: | 288.18 D |
From 32.00€
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Edatrexate
Item number: TGM-T68661-100mg
Description: Edatrexate (CGP 30694), also known as 10-Ethyl-10-deazaaminopterin, is an analog of Methotrexate that demonstrates antitumor activity against Methotrexate-resistant tumors. This antifolate antimetabolite is utilized in research related to non-small-cell lung cancer, breast cancer, non-Hodgkin's...
| Keywords: | CGP 30694 |
| Application: | Targets dihydrofolate reductase [EC:1.5.1.3] (DHFR, folA) |
| CAS | 80576-83-6 |
| MW: | 467.48 D |
From 1,491.00€
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Piritrexim isethionate
Item number: TGM-T68684-100mg
Description: Piritrexim isethionate is a lipid-soluble inhibitor of dihydrofolate reductase (DHFR) that appears to be an active agent in patients with metastatic urothelial cancer when administered as a 5-day, low-dose oral schedule. Target: Others. Smiles: OCCS(O)(=O)=O.COc1ccc(OC)c(Cc2cnc3nc(N)nc(N)c3c2C)c1
| Application: | Targets dihydrofolate reductase [EC:1.5.1.3] (DHFR, folA) |
| CAS | 79483-69-5 |
| MW: | 451.49 D |
From 1,491.00€
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CI-898 HCl
Item number: TGM-T70304-100mg
Description: CI-898 HCl is a lipophilic antifolate inhibitor of dihydrofolate reductase (DHFR). It has enhanced binding to DHFR in the presence of the cofactor NADPH. Cl-898 HCl inhibits cell growth and halts the cell cycle at the G1/S phase in L1210 mouse lymphocytic leukemia cells and is active against...
| Application: | Lipophilic antifolate DHFR inhibitor |
| CAS | 1658520-97-8 |
| MW: | 478.8 D |
From 1,491.00€
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Aminopterin
Item number: TGM-T7730-100mg
Description: Aminopterin (4-Aminofolic acid) is a synthetic folic acid derivative whose metabolite is a competitive inhibitor of dihydrofolate reductase. Target: Antifolate. Smiles: NC=1C2=C(N=CC(CNC3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)N=C(N)N1. References: Cole, P. D . Phase II Trial of Oral Aminopterin for...
| Keywords: | APGA, 4-Aminofolic acid |
| Application: | Dihydrofolate reductase inhibitor prodrug |
| CAS | 54-62-6 |
| MW: | 440.41 D |
From 41.00€
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Dihydrofolate reductase Protein, Human, Recombinant (His)
Item number: TGM-TMPH-01224-100ug
Description: Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFR2.
| Keywords: | Dihydrofolate reductase, DHFR |
| MW: | 25.5 kD |
From 193.00€
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Dihydrofolate reductase Protein, S. aureus, Recombinant...
Item number: TGM-TMPH-03535-100ug
Description: Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Dihydrofolate reductase Protein, S. aureus, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular...
| Keywords: | folA, Dihydrofolate reductase, DHFR |
| MW: | 25.6 kD |
From 352.00€
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Dihydrofolate reductase Protein, S. epidermidis,...
Item number: TGM-TMPH-03581-100ug
Description: Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Dihydrofolate reductase Protein, S. epidermidis, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is...
| Keywords: | folA1, dfrC, Dihydrofolate reductase, DHFR, folA |
| MW: | 22.0 kD |
From 352.00€
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Dihydrofolate reductase Protein, E. coli, Recombinant (His)
Item number: TGM-TMPH-00608-100ug
Description: Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
| Keywords: | folA, tmrA, Dihydrofolate reductase |
| MW: | 18.8 kD |
From 278.00€
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Methotrexate-d3
Item number: TGM-TMIH-0335-1mg
Description: Methotrexate-d3 is a deuterated compound of Methotrexate. Methotrexate has a CAS number of 59-05-2. Methotrexate is a folate analog metabolic inhibitor with immunosuppressant and antineoplastic properties. Target: ADC Cytotoxin. Smiles:...
| Application: | GC-MS, LC-MS, internal standard, DHFR inhibitor |
| CAS | 432545-63-6 |
| MW: | 457.46 D |
From 282.00€
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Pemetrexed tromethamine
Item number: TGM-T25929-100mg
Description: Pemetrexed tromethamine is a chemotherapy drug used for pleural mesothelioma and non-small cell lung cancer. Target: Others. Smiles: OCC(CO)(N)CO.OC(CC[C@@H](C(O)=O)NC(C(C=C1)=CC=C1CCC2=CNC(NC(N)=N3)=C2C3=O)=O)=O.OCC(CO)(N)CO.O.O. References: Lin L, Zhao J, Hu J, Zou G, Huang F, Han J, He Y, Cao X....
| Keywords: | Pemetrexed ditromethamine dihydrate |
| Application: | Targets thymidylate synthase [EC:2.1.1.45] (thyA, TYMS) |
| CAS | 1851348-04-3 |
| MW: | 705.72 D |
From 1,491.00€
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Methotrexate
Item number: TGM-T1485-100mg
Description: Methotrexate (WR19039) is a folate analog, an inhibitor of the dihydrofolate reductase DHFR. Methotrexate has antimetabolic, antitumor, and immunosuppressive activities, and is commonly used in rheumatoid arthritis and various tumors. Target: DNA/RNA Synthesis, Dehydrogenase, Apoptosis, ADC...
| Keywords: | Amethopterin, CL14377, NCI-C04671, WR19039 |
| Application: | Targets dihydrofolate reductase [EC:1.5.1.3] (DHFR, folA) |
| CAS | 59-05-2 |
| MW: | 454.44 D |
From 38.00€
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