36 products were found matching "K00181"!
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IWP-3
Item number: TGM-T21650-100mg
Description: IWP-3 is a potent inhibitor of Wnt production with an IC50 of 40 nM. It inhibits Porcupine (Porcn), blocking the palmitoylation of Wnt proteins, and moderately inhibits CK1gamma3 and CK1epsilon, but does not inhibit CK1alpha [1] [2]. Target: Wnt/beta-catenin. Smiles:...
| Application: | Porcupine inactivator |
| CAS | 687561-60-0 |
| MW: | 484.59 D |
From 40.00€
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IWP-2
Item number: TGM-T2702-5mg
Description: IWP-2 is a Wnt pathway inhibitor (IC50=27 nM) and an ATP-competitive CK1delta inhibitor (IC50=40 nM for M82FCK1delta). IWP-2 inhibits self-renewal of embryonic stem cells and has been used in stem cell and organoid research. Target: Porcupine, Casein Kinase, Wnt/beta-catenin. Smiles:...
| Keywords: | IWP2 |
| Application: | Porcupine inactivator |
| CAS | 686770-61-6 |
| MW: | 466.6 D |
From 45.00€
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ETC-159
Item number: TGM-T4043-100mg
Description: ETC-159 (ETC-1922159) is a potent, orally available PORCN inhibitor that inhibits beta-catenin reporter activity with an IC50 of 2.9 nM. Target: Wnt/beta-catenin, Porcupine. Smiles: Cn1c2ncn(CC(=O)Nc3ccc(nn3)-c3ccccc3)c2c(=O)n(C)c1=O. References: Madan B, et al. Wnt addiction of genetically defined...
| Keywords: | ETC159, ETC-1922159, ETC 159 |
| Application: | Porcupine (PORCN) inhibitor |
| CAS | 1638250-96-0 |
| MW: | 391.38 D |
From 45.00€
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IWP-4
Item number: TGM-T4245-100mg
Description: IWP-4 (Inhibitor of Wnt Production-4) is a potent Wnt inhibitor. Target: Wnt/beta-catenin. Smiles: COc1ccccc1-n1c(SCC(=O)Nc2nc3ccc(C)cc3s2)nc2CCSc2c1=O. References: Lian X, et al. Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling....
| Keywords: | Inhibitor of Wnt Production-4 |
| Application: | Wnt production inhibitor, porcupine inactivator |
| CAS | 686772-17-8 |
| MW: | 496.62 D |
From 42.00€
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Porcn-IN-1
Item number: TGM-T4438-100mg
Description: Porcn-IN-1 (Porcupine-IN-1) is an effective porcupine inhibitor (IC50: 0.5±0.2 nM). Target: Porcupine. Smiles: Cc1cc(ccn1)-c1ncc(CNC(=O)c2ccc3c(c2)[nH]c2ccccc32)cc1F. References: Xu Z, Xu X, O'Laoi R, et al. Design, synthesis, and evaluation of novel porcupine inhibitors featuring a fused 3-ring system...
| Keywords: | Porcupine-IN-1 |
| Application: | Protein-serine O-palmitoleoyltransferase porcupine (PORCN ) inhibitor |
| CAS | 2036044-77-4 |
| MW: | 410.44 D |
From 48.00€
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LGK974
Item number: TGM-T2618-100mg
Description: LGK974 (NVP-LGK974) is an effective and selective PORCN inhibitor and inhibits Wnt signaling (IC50: 0.4 nM) in TM3 cells. It has been used in trials studying the treatment of Metastatic Colorectal Cancer and Squamous Cell Carcinoma, Head And Neck. Target: Porcupine. Smiles:...
| Keywords: | LGK-974, LGK 974, NVP-LGK974, WNT974 |
| Application: | PORCN inhibitor |
| CAS | 1243244-14-5 |
| MW: | 396.44 D |
From 42.00€
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LGK974
Item number: Cay14072-5
Porcupine (PORCN) is a membrane bound O-acyltransferase that mediates palmitoylation of Wnt family proteins. This step is required for secretion and biologic activity of Wnt proteins, which have roles in embryonic development and cancer. LGK974 is a potent and specific small molecule inhibitor of PORCN (IC50 = 0.4...
| Keywords: | PORCN Inhibitor IV, 2',3-dimethyl-N-[5-(2-pyrazinyl)-2-pyridinyl]-[2,4'-bipyridine]-5-acetamide |
| Application: | PORCN inhibitor |
| CAS | 1243244-14-5 |
| MW: | 396.4 D |
From 52.00€
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IWP-2
Item number: Cay13951-1
Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis. Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to beta-catenin activation of gene transcription. IWP-2 is an inhibitor of Wnt production...
| Keywords: | Inhibitor of Wnt Production-2,... |
| Application: | Porcupine inactivator |
| CAS | 686770-61-6 |
| MW: | 466.6 D |
From 36.00€
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IWP-4
Item number: Cay13954-1
IWP-4 is an inhibitor of Wnt production that impairs Wnt pathway activity in vitro with an IC50 value of 25 nM. IWP-4 inactivates Porcupine, a membrane-bound O-acyltransferase responsible for palmitoylating Wnt proteins, which is essential for their signaling ability and secretion. At 5 µM, IWP-4 has been shown to...
| Keywords: | Inhibitor of Wnt Production-4,... |
| Application: | Wnt production inhibitor, Porcupine inactivator |
| CAS | 686772-17-8 |
| MW: | 496.6 D |
From 49.00€
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Wnt-C59
Item number: Cay16644-1
Porcupine (PORCN) is a membrane bound O-acyltransferase that mediates palmitoylation of Wnt family proteins. This step is required for secretion and biologic activity of Wnt proteins, which have roles in embryonic development and cancer. Wnt-C59 is a potent inhibitor of PORCN, as measured by prevention of Wnt3A...
| Keywords: | PORCN Inhibitor II, 4-(2-methyl-4-pyridinyl)-N-[4-(3-pyridinyl)phenyl]-benzeneacetamide |
| Application: | Porcupine inhibitor |
| CAS | 1243243-89-1 |
| MW: | 379.5 D |
From 61.00€
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IWP-L6
Item number: Cay15243-5
Porcupine (PORCN) is a membrane bound O-acyltransferase that mediates palmitoylation of Wnt family proteins. This step is required for secretion and biologic activity of Wnt proteins, which have roles in embryonic development and cancer. IWP-L6 is a potent inhibitor of PORCN (EC50 = 0.5 nM). It suppresses the...
| Keywords: | PORCN Inhibitor III, Wnt Pathway Inhibitor XIX,... |
| Application: | Potent PORCN inhibitor |
| CAS | 1427782-89-5 |
| MW: | 472.6 D |
From 112.00€
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LGK-974
Item number: LKT-L2540.1
LGK-974 inhibits PORCN, suppressing Wnt signaling. This compound exhibits anticancer chemotherapeutic activity and is currently in clinical trials. LGK-974 inhibits proliferation and induces differentiation of pancreatic adenocarcinoma xenografts, it also shows efficacy in suppressing tumor growth in animal models...
| Keywords: | LGK974 |
| Application: | PORCN inhibitor |
| CAS | 1243244-14-5 |
| MW: | 396.44 D |
From 109.00€
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