103 products were found matching "K00021"!
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Pitavastatin lactone
Item number: TGM-T12490-10mg
Description: Pitavastatin lactone is the major metabolite of Pitavastatin in humans.Pitavastatin is a competitive inhibitor of HMG-CoA reductase. Target: HMG-CoA Reductase, Others. Smiles: C(=C/[C@@H]1C[C@@H](O)CC(=O)O1)\C2=C(C3=C(N=C2C4CC4)C=CC=C3)C5=CC=C(F)C=C5. References: Fujino H, et al. Metabolic fate of...
| Application: | HMG-CoA reductase inhibitor |
| CAS | 141750-63-2 |
| MW: | 403.45 D |
From 65.00€
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Rosuvastatin
Item number: TGM-T1676-100mg
Description: Rosuvastatin (ZD 4522) is an antilipemic agent that competitively inhibits hydroxymethyl-glutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Rosuvastatin belongs to a class of medications...
| Keywords: | ZD 4522 |
| Application: | Targets hydroxymethylglutaryl-CoA reductase (NADPH) [EC:1.1.1.34] (HMGCR) |
| CAS | 287714-41-4 |
| MW: | 481.54 D |
From 45.00€
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Fluvastatin sodium
Item number: TGM-T1487-100mg
Description: Fluvastatin sodium (Fluvastatin sodium salt), a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR), is a commonly used cholesterol lowering agent. Target: Autophagy, Ferroptosis, HMG-CoA Reductase. Smiles:...
| Keywords: | XU 62320 sodium, XU-62-320, Fluvastatin sodium salt |
| Application: | Targets hydroxymethylglutaryl-CoA reductase (NADPH) [EC:1.1.1.34] (HMGCR) |
| CAS | 93957-55-2 |
| MW: | 433.45 D |
From 31.00€
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Atorvastatin lactone
Item number: TGM-T14342-100mg
Description: Atorvastatin lactone is a prodrug form of atorvastatin. Which is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor. Target: HMG-CoA Reductase. Smiles: CC(C)c1c(C(=O)Nc2ccccc2)c(c(-c2ccc(F)cc2)n1CC[C@@H]1C[C@@H](O)CC(=O)O1)-c1ccccc1. References: Valesky RJ, et al....
| Application: | Atorvastatin (HMG-CoA reductase inhibitor) prodrug |
| CAS | 125995-03-1 |
| MW: | 540.62 D |
From 33.00€
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Cerivastatin
Item number: TGM-T14931-100mg
Description: Cerivastatin is a highly potent, well-tolerated, and orally active HMG-CoA reductase inhibitor (Ki: 1.3 nM/L). Cerivastatin also inhibits proliferation and invasiveness of MDA-MB-231 cells, mainly by RhoA inhibition with anti-cancer effect. Cerivastatin reduces low-density lipoprotein cholesterol...
| Application: | Targets hydroxymethylglutaryl-CoA reductase (NADPH) [EC:1.1.1.34] (HMGCR) |
| CAS | 145599-86-6 |
| MW: | 459.55 D |
From 2,080.00€
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Rosuvastatin calcium
Item number: TGM-T1510-100mg
Description: Rosuvastatin calcium (ZD4522) , a selective and competitive inhibitor of hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, has antilipidemic activity. Target: HMG-CoA Reductase, Potassium Channel, Autophagy. Smiles:...
| Keywords: | ZD4522, ZD 4522 Calcium, Rosuvastatin hemicalcium |
| Application: | Targets hydroxymethylglutaryl-CoA reductase (NADPH) [EC:1.1.1.34] (HMGCR) |
| CAS | 147098-20-2 |
| MW: | 1001.14 D |
From 30.00€
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Simvastatin acid ammonium
Item number: TGM-T16885-10mg
Description: Simvastatin ammonium is an active metabolite of simvastatin lactone mediated. Simvastatin ammonium reduces indoxyl sulfate-mediated reactive oxygen species and modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene. Target: Others. Smiles:...
| Keywords: | Tenivastatin ammonium |
| Application: | HMG-CoA reductase inhibitor |
| CAS | 139893-43-9 |
| MW: | 453.62 D |
From 39.00€
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Atorvastatin calcium trihydrate
Item number: TGM-T21363-5mg
Description: Atorvastatin is used to inhibits HMG-CoA reductase for lowering blood cholesterol and for prevention of events associated with cardiovascular disease. Target: Others. Smiles: C(NC1=CC=CC=C1)(=O)C=2C(=C(N(CC[C@H](C[C@H](CC(O)=O)O)O)C2C(C)C)C3=CC=C(F)C=C3)C4=CC=CC=C4.[Ca].O. References: Delgado-Montero A,...
| Keywords: | Atorvastatin, CI981, CI 981, CI-981, atorvastatin, calcium salt |
| Application: | Targets hydroxymethylglutaryl-CoA reductase (NADPH) [EC:1.1.1.34] (HMGCR) |
| CAS | 344423-98-9 |
| MW: | 1209.39 D |
50.00€
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Fluvastatin
Item number: TGM-T21405-10mg
Description: Fluvastatin (XU-62320) is a potent and competitive HMG-CoA reductase inhibitor (IC50: 8 nM) that inhibits oxidative stress in vascular smooth muscle cells through an Nrf2-dependent pathway, and is used for the reduction of plasma cholesterol levels and the prevention of cardiovascular disease. Target:...
| Keywords: | Lescol, Cranoc, Vastin, XU-62320, Canef |
| Application: | Targets hydroxymethylglutaryl-CoA reductase (NADPH) [EC:1.1.1.34] (HMGCR) |
| CAS | 93957-54-1 |
| MW: | 411.47 D |
From 31.00€
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SR12813
Item number: TGM-T6994-100mg
Description: SR12813 (GW 485801) is a pregnane X receptor (PXR) agonist. Target: HMG-CoA Reductase, Autophagy. Smiles: P(C(P(OCC)(OCC)=O)=CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1)(OCC)(OCC)=O. References: Jones SA, et al. Mol Endocrinol. 2000, 14(1):27-39.
| Keywords: | GW 485801, SR 12813, SR-12813 |
| Application: | HMG-CoA reductase degradation enhancer, pregnane X receptor ligand |
| CAS | 126411-39-0 |
| MW: | 504.53 D |
From 50.00€
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(3R,5R)-Rosuvastatin calcium
Item number: TGM-T84962-10mg
Description: (3R,5R)-Rosuvastatin, a potential impurity detected in bulk rosuvastatin formulations, arises as a degradation product through various stresses including acid or base hydrolysis, thermal, photolytic, hydrolytic, oxidative stress, or during storage. This compound is associated with the HMG-CoA reductase...
| Application: | Potential rosuvastatin preparation impurity |
| CAS | 1422515-55-6 |
| MW: | 500.6 D |
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HMGCR Protein, Mouse, Recombinant (His)
Item number: TGM-TMPH-02476-100ug
Description: Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol homeostasis. HMGCR Protein, Mouse, Recombinant (His) is expressed in E. coli...
| Keywords: | Hmgcr, 3-hydroxy-3-methylglutaryl-coenzyme A reductase |
| MW: | 20.4 kD |
From 278.00€
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