10 products were found matching "GeneID 29881"!

Recombinant human NPC1L1 protein with C-terminal 6×His tag. NPC1L1(Glu22-Ser284) 6×His tag, Protein function: Plays a major role in cholesterol homeostasis. Is critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Is the direct molecular target of ezetimibe, a drug that...

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Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 22-284aa. Protein Length: Partial. Tag Info: N-terminal 6xHis-tagged and C-terminal HA-tagged. Target Protein Sequence: EPYTTIHQPG YCAFYDECGK NPELSGSLMT LSNVSCLSNT PARKITGDHL ILLQKICPRL YTGPNTQACC SAKQLVSLEA SLSITKALLT RCPACSDNFV NLHCHNTCSP...

Protein function: Plays a major role in cholesterol homeostasis. Is critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorption. Lack of activity leads to multiple lipid transport defects. The...

Length: 3999 Sequence: atggcggagg ccggcctgag gggctggctg ctgtgggccc tgctcctgcg cttggcccag agtgagcctt acacaaccat ccaccagcct ggctactgcg ccttctatga cgaatgtggg aagaacccag agctgtctgg aagcctcatg acactctcca acgtgtcctg cctgtccaac acgccggccc gcaagatcac aggtgatcac ctgatcctat tacagaagat ctgcccccgc ctctacaccg gccccaacac...

Protein function: Plays a major role in cholesterol homeostasis (PubMed:22095670). Critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte (PubMed:22095670). Involved in plant sterol absorption, it transports sitosterol, although at lower rates than cholesterol. Is the direct...

Primers are provided as a 40 µl solution containing both primers at a final concentration of 50 µM in 10 mM Tris-HCl (pH 7.5), 0.1 mM EDTA. Dilute with water as needed prior to use. This amount is sufficient for 1000 x 20µl PCR reactions assuming a final primer concentration of 0.1 µM. Add cDNA template....

The protein encoded by this gene is a multi-pass membrane protein. It contains a conserved N-terminal Niemann-Pick C1 (NPC1) domain and a putative sterol-sensing domain (SSD) which includes a YQRL motif functioning as a plasma membrane to trans-Golgi network transport signal in other proteins. This protein takes up...

Niemann-Pick C1-like 1 (NPC1L1) is a transmembrane protein that plays a critical role in cholesterol absorption (1). It is highly expressed in small intestine and localized along the brush border in both human and mouse (2,3). NPC1L1 mediates cholesterol uptake via its vesicular endocytosis (4). Ezetimibe, a potent...

Protein function: Plays a major role in cholesterol homeostasis. Is critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorption. Lack of activity leads to multiple lipid transport defects. The...