Protein function: Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Can also transport ammonium in the distal nephron. Produces a large instantaneous current. [The UniProt Consortium]

Anti-HCN2 Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with HCN2 from Human, Rat, and Mouse based on 100% homology with the immunizing sequence. No cross-reactivity against HCN1. Cross-reactivity with HCN2 from other sources has not been determined....

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological , cells because their main function is...