Description: Finasteride (MK-906) is an oral inhibitor of active testosterone 5-alpha-reductase and Ki value is 10 nM. Target: Reductase. Smiles: C[C@@]12[C@]([C@]3([C@@]([C@]4(C)[C@@](CC3)(NC(=O)C=C4)[H])(CC1)[H])[H])(CC[C@@H]2C(NC(C)(C)C)=O)[H]. References: Azzolina B, et al. J Steroid Biochem Mol Biol, 1997,...

Finasteride is a 4-azasteroid competitive inhibitor of 5alpha-reductase type II (IC50 = 4.2 nM) and a derivative of testosterone. It is 100-fold selective for 5alpha-reductase type II over type I. Finasteride (10 µM) does not affect the growth of androgen-refractory PC3 prostate cancer cells but increases the...

White to off-white solid. Soluble in DMSO, DMF, ethanol or methanol. Sparingly soluble in water. Potent, specific and competitive inhibitor of type II 5alpha-reductase (enzyme which converts testosterone to the more potent 5alpha-dihydrotestosterone), Anticancer compound, Apoptosis modulator, Enhances the action of...

Finasteride is a synthetic 4-azasteroid. It is a specific inhibitor of the enzyme steroid 5-alpha-reductase which is responsible for the conversion of testosterone into the potent androgen 5alpha-dihydrotestosterone.

C 72.39% H 7.13% N 7.34% O 8.39% D 4.75%