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Item number: TGM-T8332-100mg

Description: Bipenquinate is a potent and selective inhibitor of dihydroorotate dehydrogenase (DHODH) with IC50 of 20 nM, blocking de novo pyrimidine biosynthesis. Target: Dehydrogenase. Smiles: [Na+].Cc1c(nc2ccc(F)cc2c1C([O-])=O)-c1ccc(cc1)-c1ccccc1F. References: Li S F , Gong M J , Sun Y F , et al. Antiviral...

Application:	Targets dihydroorotate dehydrogenase [EC:1.3.5.2] (DHODH, pyrD)
CAS	96201-88-6
MW:	397.36 D

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Brequinar (sodium salt)

Item number: Cay36183-10

Brequinar is an inhibitor of dihydroorotate dehydrogenase (DHODH, IC50 = ~20 nM), the enzyme that converts dihydroorotate to orotate during de novo pyrimidine synthesis. Brequinar is selective for DHODH over a panel of greater than 400 kinases at 100 nM. It induces differentiation of ER-HoxA9, U937, and THP-1 cells...

Keywords:	DuP-785, NSC 368390, 6-fluoro-2-(2'-fluoro[1,1'-biphenyl]-4-yl)-3-methyl-4-quinolinecarboxylic acid, monosodium salt
Application:	DHODH inhibitor
CAS	96201-88-6
MW:	397.4 D

From 92.00€ *

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