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Item number: Cay24445-1

Brequinar is an inhibitor of dihydroorotate dehydrogenase (DHODH, IC50 = ~20 nM), the enzyme that converts dihydroorotate to orotate during de novo pyrimidine synthesis. Brequinar is selective for DHODH over a panel of greater than 400 kinases at 100 nM. It induces differentiation of ER-HoxA9, U937, and THP-1 cells...

Keywords:	NSC 368390, 6-fluoro-2-(2'-fluoro[1,1'-biphenyl]-4-yl)-3-methyl-4-quinolinecarboxylic acid
Application:	DHODH inhibitor
CAS	96187-53-0
MW:	375.4 D

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