Description: Devimistat (6,8-Bis(benzylthio)octanoic acid) , a lipoate analog, inhibits mitochondrial enzymes pyruvate dehydrogenase (PDH) and alpha-ketoglutarate dehydrogenase, disrupts tumor cell mitochondrial metabolism. It has potential chemopreventive and antineoplastic activities, and has been used in trials...

CPI-613 is a lipoic acid analog that inhibits alpha-ketoglutarate dehydrogenase, particularly in tumor cells. At 60-240 µM, CPI-613 induces a strong mitochondrial burst of reactive oxygen species, resulting in cell death. By disrupting mitochondrial metabolism, CPI-613 demonstrates both in vitro and in vivo...