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LCQ-908
Item number: Cay42025-1
LCQ-908 is an inhibitor of diacylglycerol acyltransferase 1 (DGAT1, IC50 = 57 nM). It is selective for DGAT1 over DGAT2, acyl-coenzyme A:cholesterol acyltransferase-1 (ACAT-1), and ACAT-2 (IC50s = >10,000 nM for all). LCQ-908 (50 µM) also inhibits hepatitis C virus (HCV) replication in HCV-infected Huh7.5 cells. It...
| Keywords: | Pradigastat, trans-4-[4-[5-[[6-(trifluoromethyl)-3-pyridinyl]amino]-2-pyridinyl]phenyl]-cyclohexaneacetic acid |
| Application: | DGAT1 inhibitor |
| CAS | 956136-95-1 |
| MW: | 455.5 D |
From 35.00€
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Pradigastat
Item number: TGM-T11827-1mg
Description: Pradigastat (LCQ-908) is an orally active, potent and selective diacylglycerol acyltransferase 1 (DGAT1) inhibitor for the treatment of constipation, which may be used in the study of obesity and diabetes. Target: Transferase. Smiles: OC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)-c1ccc(Nc2ccc(nc2)C(F)(F)F)cn1....
| Keywords: | ANJ908, LCQ908-NXA, LCQ-908, LCQ908A |
| Application: | Targets diacylglycerol O-acyltransferase 1 [EC:2.3.1.20 2.3.1.75 2.3.1.76] (DGAT1) |
| CAS | 956136-95-1 |
| MW: | 455.47 D |
From 110.00€
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