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Danirixin
Item number: TGM-T5193-100mg
Description: Danirixin (GSK1325756) is a potent antagonist of CXCR2 that inhibits IL-8 binding to CXCR2 (IC50: 12.5 nM). Target: CXCR. Smiles: Cl.Cc1c(F)cccc1NC(=O)Nc1ccc(Cl)c(c1O)S(=O)(=O)[C@H]1CCCNC1. References: Miller BE, et al. The pharmacokinetics and pharmacodynamics of danirixin (GSK1325756)--a selective...
| Keywords: | GSK1325756 |
| Application: | Targets C-X-C chemokine receptor type 2 (CXCR2, IL8RB, CD182) |
| CAS | 954126-98-8 |
| MW: | 441.9 D |
From 57.00€
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Danirixin
Item number: Cay20980-25
Danirixin is an antagonist of chemokine (C-X-C motif) receptor 2 (CXCR2, IC50 = 12.5 µM). It is selective for CXCR2 over CXCR1 (IC50 = 977 nM). Danirixin inhibits IL-8-induced calcium mobilization in CHO-K1 cells expressing human CXCR2 (pA2 = 7.52). It inhibits neutrophil surface expression of CD11b in isolated rat...
| Keywords: | GSK1325756, GSK1325756B, N-[4-chloro-2-hydroxy-3-[(3S)-3-piperidinylsulfonyl]phenyl]-N'-(3-fluoro-2-methylphenyl)-urea |
| Application: | Antiinflammatory, Chemokine (C-X-C motif) receptor 2 antagonist |
| CAS | 954126-98-8 |
| MW: | 441.9 D |
From 55.00€
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