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Item number: Cay20980-25

Danirixin is an antagonist of chemokine (C-X-C motif) receptor 2 (CXCR2, IC50 = 12.5 µM). It is selective for CXCR2 over CXCR1 (IC50 = 977 nM). Danirixin inhibits IL-8-induced calcium mobilization in CHO-K1 cells expressing human CXCR2 (pA2 = 7.52). It inhibits neutrophil surface expression of CD11b in isolated rat...

Keywords:	GSK1325756, GSK1325756B, N-[4-chloro-2-hydroxy-3-[(3S)-3-piperidinylsulfonyl]phenyl]-N'-(3-fluoro-2-methylphenyl)-urea
Application:	Antiinflammatory, Chemokine (C-X-C motif) receptor 2 antagonist
CAS	954126-98-8
MW:	441.9 D

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