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Item number: Cay21945-1

BCI is an inhibitor of dual specificity phosphatase 6 (DUSP6) and DUSP1. (E/Z)-BCI (0.5-2 µM) inhibits LPS-induced expression of Dusp6 in a concentration-dependent manner and increases nuclear protein levels of Nrf2 in RAW 264.7 macrophages. It also inhibits LPS-induced increases in the production of IL-1beta, IL-6,...

Keywords:	3-(cyclohexylamino)-2,3-dihydro-2-(phenylmethylene)-1H-inden-1-one, monohydrochloride
Application:	Dusp6 inhibitor
CAS	95130-23-7
MW:	353.9 D

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