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Item number: TGM-T3987-100mg

Description: Lotamilast (RVT-501) is a phosphodiesterase 4 (PDE-4) inhibitor (IC50: 2.8 nM) potentially for the treatment of atopic dermatitis. Target: PDE. Smiles: CNc1nc(-c2cccc(NC(=O)c3ccc(cc3)C(=O)OC)c2)c2cc(OC)c(OC)cc2n1. References: Nemoto O., et al. Effect of topical phosphodiesterase 4 inhibitor E6005 on...

Keywords:	RVT-501, E6005
Application:	Targets cAMP-specific phosphodiesterase 4 [EC:3.1.4.53] (PDE4)
CAS	947620-48-6
MW:	472.49 D

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E6005

Item number: Cay30203-1

E6005 is an inhibitor of phosphodiesterase 4 (PDE4, IC50 = 2.8 nM). It is selective for PDE4 over PDE1, PDE2, PDE3, and PDE5 with only 46.1, 51.6, 69.4, and 57.4% inhibition, respectively, at 30 µM. It inhibits the production of various cytokines in isolated human lymphocytes and monocytes (IC50s = 0.49-3.1 nM)....

Keywords:	RVT-501, 4-[[[3-[6,7-dimethoxy-2-(methylamino)-4-quinazolinyl]phenyl]amino]carbonyl]-benzoic acid, methyl ester
Application:	PDE4 inhibitor
CAS	947620-48-6
MW:	472.5 D

From 49.00€ *

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