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Ro 5126766
Item number: TGM-T6971-100mg
Description: RO5126766 (CH5126766) is a dual RAF/MEK inhibitor with IC50 of 8.2 nM, 19 nM, 56 nM, and 160 nM for BRAF V600E, BRAF, CRAF, and MEK1, respectively. Phase 1. Target: Raf, MEK. Smiles: CNS(=O)(=O)Nc1nccc(Cc2c(C)c3ccc(Oc4ncccn4)cc3oc2=O)c1F. References: Ishii N, et al. Cancer Res. 2013, 73(13), 4050-4060.
| Keywords: | CH5126766, Avutometinib, RO5126766, VS-6766 |
| Application: | Targets mitogen-activated protein kinase kinase 1 [EC:2.7.12.2] (MAP2K1, MEK1) |
| CAS | 946128-88-7 |
| MW: | 471.46 D |
From 52.00€
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Ro 5126766
Item number: Cay29197-1
Ro 5126766 is a dual inhibitor of MEK1 (IC50 = 160 nM) and Raf kinases (IC50s = 56, 19, and 8.2 nM for C-RAF, B-RAF, and B-RAFV600E, respectively). It is selective for these kinases over a panel of 254 additional kinases at 10 µM. Ro 5126766 (1 µM) decreases MEK and ERK phosphorylation in a panel of seven cancer...
| Keywords: | CH5126766, N-[3-fluoro-4-[[4-methyl-2-oxo-7-(2-pyrimidinyloxy)-2H-1-benzopyran-3-yl]methyl]-2-pyridinyl]-N'-methyl-sulfamide |
| Application: | MEK1 / RAF kinases dual inhibitor |
| CAS | 946128-88-7 |
| MW: | 471.5 D |
From 102.00€
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