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SAG 21k
Item number: TGM-T35559-100mg
Description: SAG 21k is an orally bioactive and potent Hedgehog signaling activator that crosses the blood-brain barrier for the study of cartilage regeneration. Target: Hedgehog/Smoothened. Smiles: ClC=1C=2C(SC1C(N(CC3=C(OC)C=CC(=C3)C=4C=CN=CC4)[C@H]5CC[C@H](NC)CC5)=O)=C(F)C=CC2F. References: Christopher Loose,et...
| Application: | Hedgehog signaling pathway agonist |
| CAS | 946002-48-8 |
| MW: | 556.07 D |
From 114.00€
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SAG 21k
Item number: Cay41121-10
SAG 21k is an agonist of the hedgehog signaling pathway. It activates the Smoothened receptor (Smo) in a reporter assay using C3H/10T1/2 cells expressing Smo (EC50 = 0.3 nM). SAG 21k (1 nM) increases the levels of mRNA encoding Ki67, coiled-coil domain-containing protein 1 (Ccdc1), collagen II, alkaline phosphatase...
| Keywords: | 3-chloro-4,7-difluoro-N-[[2-methoxy-5-(4-pyridinyl)phenyl]methyl]-N-[trans-4-(methylamino)cyclohexyl]-benzo[b]thiophene-2-... |
| Application: | Hedgehog signaling pathway agonist |
| CAS | 946002-48-8 |
| MW: | 556.1 D |
From 234.00€
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