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XL019
Item number: TGM-T3072-100mg
Description: XL019 is a potent and selective JAK2 inhibitor with IC50 of 2.2 nM, 100 fold selectivity over JAK1. Target: Apoptosis, FLT, PDGFR, JAK. Smiles: O=C(Nc1ccc(cc1)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1)[C@@H]1CCCN1. References: Forsyth T, et al. Bioorg Med Chem Lett, 2012, 22(24), 7653-7658.
| Application: | JAK2 inhibitor |
| CAS | 945755-56-6 |
| MW: | 444.53 D |
From 67.00€
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XL019
Item number: Cay16298-1
Janus-associated kinases (JAKs) are cytoplasmic tyrosine kinases that are required for activating the signaling of certain cytokines and growth factor receptors. Many myeloproliferative diseases have been linked to a mutation in JAK2 where a switch from valine to phenylalanine occurs at the 617 position (V617F)....
| Keywords: | (2S)-N-[4-[2-[[4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]phenyl]-2-pyrrolidinecarboxamide |
| Application: | JAK2 inhibitor |
| CAS | 945755-56-6 |
| MW: | 444.5 D |
From 34.00€
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