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TASP 0277308
Item number: TGM-T41145-5mg
Description: TASP 0277308 is a potent and selective sphingosine 1-phosphate 1 (S1P1) receptor antagonist (IC50 = 7.8 nM). TASP 0277308 inhibits S1P-induced chemotaxis (IC50 = 1.1-1.6 nM), HUVEC cell proliferation (IC50 = 3-3.6 nM) and suppresses angiogenesisin vivo. TASP 0277308 also blocks VEGF-induced...
| Application: | S1P1 antagonist |
| CAS | 945725-50-8 |
| MW: | 539.48 D |
777.00€
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TASP0277308
Item number: Cay11340-1
TASP0277308 is a sphingosine-1-phosphate receptor 1 (S1P1) antagonist (IC50 = 4.2 nM). It is selective for S1P1 over S1P3, S1P4, and S1P5 (IC50s = >10,000, >10,000, and 8,756 nM, respectively). TASP0277308 inhibits S1P-induced [35S]GTPgammaS binding and forskolin-induced cAMP production in HEK293 cells expressing...
| Keywords: | 3,4-dichloro-N-[(1R)-1-[4-ethyl-5-[3-(4-methyl-1-piperazinyl)phenoxy]-4H-1,2,4-triazol-3-yl]ethyl]-benzenesulfonamide |
| Application: | S1P1 antagonist |
| CAS | 945725-50-8 |
| MW: | 539.5 D |
From 74.00€
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