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Pexmetinib
Item number: TGM-T6934-100mg
Description: Pexmetinib (ARRY-614) (ARRY-614) is a potent, orally bioavailable, dual p38 MAPK/Tie-2 inhibitor with IC50 of 4 nM/18 nM in a HEK-293 cell line. Phase 1. Target: Autophagy, p38 MAPK, Tie-2. Smiles: Cc1ccc(cc1)-n1nc(cc1NC(=O)NCc1cc(F)ccc1Oc1ccc2n(CCO)ncc2c1)C(C)(C)C. References: Koch K. 2013 AACR...
| Keywords: | ARRY-614 |
| Application: | Tie2 inhibitor, p38 MAPK inhibitor |
| CAS | 945614-12-0 |
| MW: | 556.63 D |
From 55.00€
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Pexmetinib
Item number: Cay26187-10
Pexmetinib is a dual inhibitor of Tie2 and p38 MAPK (IC50s = 1, 26, and 35 nM for Tie2, p38alpha, and p38beta, respectively). It also inhibits Abl, ARG, FGFR, FLT1, FLT4, Fyn, HCK, LYN, and MINK (IC50s = 4, 10, 28, 47, 42, 41, 26, 25, and 26 nM, respectively). Pexmetinib (0.5 and 1 µM) reduces proliferation of KG-1...
| Keywords: | ARRY 614,... |
| Application: | Tie2 inhibitor, p38 MAPK inhibitor |
| CAS | 945614-12-0 |
| MW: | 556.6 D |
From 52.00€
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