Description: H-151 is a highly potent and selective STING antagonist. H-151 covalently binds to Cys91 of STING and inhibits palmitoylation of Cys91, thereby inhibiting STING activity. H-151 can be used in the study of autoinflammatory diseases in vivo and ex vivo. Target: STING. Smiles:...

H-151 is an inhibitor of stimulator of interferon genes (STING). It forms an adduct with mouse STING in serum and acts in an irreversible manner. It inhibits the type I interferon (IFN) response and reduces the phosphorylation of TBK1 and palmitoylation of human STING (hsSTING) in vitro. It also reduces increases in...