Description: 6-(Dimethylamino)purine (N,N-Dimethyladenine) is a serine threonine protein kinase and CDK inhibitor. Target: Serine/threonin kinase, CDK. Smiles: CN(C)c1ncnc2nc[nH]c12. References: Nakashima M , Cui Z G , Tabuchi Y , et al. Apoptosis induced by an alkylated purine, 6-dimethylaminopurine, and changes...

White solid. Soluble in DMF. A puromycin analog that acts as a protein kinase inhibitor. Selectively induces premature mitosis in mammalian cells. Inhibits TNF-alpha upregulation of ICAM-1, lipolysis, and the activation of JNK/SAPK. Inhibits p34cdc2/cyclin B (IC50 = 300 µM). Induces apoptosis in S-phase-arrested...

6-(Dimethylamino)purine (6-DMAP) is a non-selective protein kinase inhibitor. It enhances the inactivation of MAPK and induces the formation of pronuclei in primary mouse oocytes. 6-DMAP (0.6-12 mM) also induces pronuclear formation, cortical contraction, and cortical granule breakdown, markers of oocyte activation,...