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Item number: Cay31411-5

Tucatinib is an inhibitor of HER2 (IC50 = 14 nM). It inhibits the phosphorylation of HER2 in BT474 breast carcinoma cells (IC50 = 21 nM). Tucatinib inhibits phosphorylation of AKT and induces apoptosis in BT474 cells. In vivo, tucatinib (25-100 mg/kg) inhibits tumor growth in NCI N87 gastric carcinoma and SKOV3...

Keywords:	ARRY-380, ONT-380,...
Application:	HER2 inhibitor
CAS	937263-43-9
MW:	480.5 D

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