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MK-4101
Item number: TGM-T6891-100mg
Description: MK-4101, an effective inhibitor of the Hedgehog pathway, has anti-tumor activity through the induction of extensive apoptosis and inhibition of proliferation in tumor cells. Target: Apoptosis, Smo, Hedgehog/Smoothened. Smiles: Cn1c(nnc1C12CCC(CC1)(CC2)c1noc(n1)C1CC(F)(F)C1)-c1ccccc1C(F)(F)F....
| Application: | Smoothened receptor antagonist |
| CAS | 935273-79-3 |
| MW: | 493.47 D |
From 39.00€
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MK-4101
Item number: Cay29159-1
MK-4101 is a Smoothened (Smo) receptor antagonist. It binds to human recombinant Smo expressed in HEK293T cells (IC50 = 1.1 µM) and inhibits Gli1-mediated hedgehog signaling in a reporter assay (IC50 = 1.5 µM). It is also an inhibitor of 11beta-hydroxy steroid dehydrogenase-1. MK-4101 (40 and 80 mg/kg per day)...
| Keywords: | 5-(3,3-difluorocyclobutyl)-3-[4-[4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl]bicyclo[2.2.2]oct-1-yl]-1,2,... |
| Application: | Smoothened receptor antagonist |
| CAS | 935273-79-3 |
| MW: | 493.5 D |
From 50.00€
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