3 products were found matching "934660-93-2"!
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Cobimetinib, Free Base
Item number: LC-C-1100_50mg
Soluble in DMSO. Cobimetinib demonstrated a sustained tumor pharmacodynamic response due to longer residence times in tumor tissue than in plasma in mice. Following single doses, cobimetinib inhibited pERK in tumors with IC50 values of 780 nM in WM-266-4 and 520 nM in A375 xenograft mice. Following multiple doses,...
| Keywords: | GDC0973, RG7420, XL518 |
| Application: | Antineoplastic, Mitogen-activated extracellular signal-regulated kinase (MEK) inhibitor |
| CAS | 934660-93-2 |
| MW: | 531.31 D |
From 87.00€
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Cobimetinib
Item number: Cay19563-1
Cobimetinib is a potent, orally available inhibitor of MEK1 (IC50 = 4.2 nM). It shows more than 100-fold selectivity for MEK when tested against a panel of more than 100 serine-threonine and tyrosine kinases. Cobimetinib induces differentiation and apoptosis in cancer cell lines and is more effective when combined...
| Keywords: | GDC-0973, RG-7420, XL518,... |
| Application: | Antineoplastic, MEK inhibitor |
| CAS | 934660-93-2 |
| MW: | 531.3 D |
From 66.00€
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GDC-0973
Item number: LKT-G124084.5
MEK1 inhibitor.
| Keywords: | GDC 0973, GDC0973, XL-518, XL 518, XL518, Cobimetinib, RG-7420, RG 7420, RG7420 |
| Application: | Mitogen-activated protein (MAP)/extracellular signal-regulated kinase (ERK) kinase (MEK) inhibitor |
| CAS | 934660-93-2 |
| MW: | 531.32 D |
From 108.00€
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