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Raxatrigine hydrochloride
Raxatrigine hydrochloride

Item number: TGM-T14992-100mg

Description: Raxatrigine hydrochloride is a state-dependent sodium channel blocker and a Nav1.7 sodium channel inhibitor. Target: Others. Smiles: Cl.NC(=O)[C@@H]1CC[C@@H](N1)c1ccc(OCc2ccccc2F)cc1. References: Large CH, et al. The efficacy of sodium channel blockers to prevent phencyclidine-induced cognitive...
Keywords: CNV1014802 (hydrochloride), GSK-1014802 hydrochloride
Application: Targets voltage-gated sodium channel type IX alpha (SCN9A, NAV1.7)
CAS 934240-31-0
MW: 350.82 D
From 86.00€ *
Review
Raxatrigine (hydrochloride)
Raxatrigine (hydrochloride)

Item number: Cay23490-5

Raxatrigine is an inhibitor of voltage-gated sodium channels (Nav, IC50s = 22, 13, 23, 10, 84, 15, 32, and 6 µM for Nav1.1-Nav1.8 channels in a FLIPR membrane potential assay using HEK293 cells). Its activity is state-dependent at the Nav1.7 channel, with a nine-fold increase in potency for the open/inactivated...
Keywords: GSK1014802A, (2S)-5R-[4-[(2-fluorophenyl)methoxy]phenyl]-2-pyrrolidinecarboxamide, monohydrochloride
Application: Voltage-gated sodium channel inhibitor
CAS 934240-31-0
MW: 350.8 D
From 50.00€ *
Review