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DG051
Item number: TGM-TQ0047-100mg
Description: DG051 is a potent leukotriene A4 hydrolase (LTA4H) inhibitor with an IC50 of 47 nM. Target: Aminopeptidase. Smiles: Cl.OC(=O)CCCN1CCC[C@H]1COc1ccc(Oc2ccc(Cl)cc2)cc1. References: Sandanayaka V, et al. Discovery of 4-[(2S)-2-{[4-(4-chlorophenoxy)phenoxy]methyl}-1-pyrrolidinyl]butanoic acid (DG-051) as a...
| Application: | LTA4H inhibitor |
| CAS | 929915-58-2 |
| MW: | 426.33 D |
From 31.00€
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DG-051
Item number: Cay21688-1
DG-051 is a potent, orally bioavailable leukotriene A4 hydrolase (LTA4H) inhibitor (Kd = 25 nM, IC50 = 47 nM), the enzyme that catalyzes the rate-determining step in the synthesis of LTB4 (Cay-20110). However, it also inhibits the aminopeptidase activity of LTA4H with IC50 values of 72 and 150 nM when tested using...
| Keywords: | (2S)-2-[[4-(4-chlorophenoxy)phenoxy]methyl]-1-pyrrolidinebutanoic acid, monohydrochloride |
| Application: | LTA4H inhibitor |
| CAS | 929915-58-2 |
| MW: | 426.3 D |
From 44.00€
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