Description: HNHA is an inhibitor of HDAC. Target: HDAC. Smiles: ONC(=O)CCCCCCSc1ccc2ccccc2c1. References: Dong H K , Lee J , Kim K N , et al. Anti-tumor activity of N-hydroxy-7-(2-naphthylthio) heptanomide, a novel histone deacetylase inhibitor[J]. Biochemical & Biophysical Research Communications, 2007,...

HNHA is a cell-permeable inhibitor of histone deacetylase (HDAC) activity (IC50 = 100 nM). In human fibrosarcoma HT1080 cells, it induces histone hyperacetylation and p21 transcription with concomitant inhibition of cell cycle progression (IC50 ~7.5 µM). HNHA is at least as effective as SAHA in inhibiting tumor...