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KU-60019
Item number: TGM-T63872-100mg
Description: KU-60019 is a specific inhibitor of ATM kinase (IC50: 6.3 nM). Target: ATM/ATR. Smiles: C[C@H]1CN(CC(=O)Nc2ccc3Sc4c(Cc3c2)cccc4-c2cc(=O)cc(o2)N2CCOCC2)C[C@@H](C)O1. References: Golding SE, et al. Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK...
| Application: | ATM kinase inhibitor |
| CAS | 925701-46-8 |
| MW: | 547.67 D |
From 33.00€
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Ku-60019
Item number: Cay17502-1
Ataxia-telangiectasia mutated (ATM) is a serine/threonine kinase that activates checkpoint signaling following double strand DNA breaks and genotoxic stress. Ku-60019 is a potent, reversible inhibitor of ATM kinase (IC50 = 6.3 nM), blocking the phosphorylation of ATM substrate proteins. It is much less effective or...
| Keywords: | rel-2R,6S-dimethyl-N-[5-[6-(4-morpholinyl)-4-oxo-4H-pyran-2-yl]-9H-thioxanthen-2-yl]-4-morpholineacetamide |
| Application: | ATM kinase inhibitor |
| CAS | 925701-46-8 |
| MW: | 547.7 D |
From 39.00€
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