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Item number: TGM-T21527-100mg

Description: HBX 41108 (HBX-41108) is a non-competitive, reversible inhibitor of USP7 with an IC50 of 424nM. HBX 41108 inhibited deubiquitination of p53 mediated by USP7 in a dose-dependent manner with an IC50 of 0.8µM. Target: DUB, p53. Smiles: Clc1ccc-2c(c1)C(=O)c1nc(C#N)c(nc-21)C#N. References: Colland F,...

Keywords:	HBX-41108
CAS	924296-39-9
MW:	266.64 D

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HBX 41108

Item number: Cay23759-1

HBX 41108 is an uncompetitive, reversible inhibitor of ubiquitin-specific protease 7 (USP7) activity (IC50 = 424 nM). It dose-dependently inhibits USP7-mediated p53 deubiquitination in a cell-free assay, with an IC50 value of approximately 0.8 µM, as well as in HEK293 cells. It is selective for USP7 over a panel of...

Keywords:	7-chloro-9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile
Application:	USP7 inhibitor
CAS	924296-39-9
MW:	266.6 D

From 52.00€ *

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