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SCH529074
Item number: TGM-T37042-100mg
Description: SCH529074 is a selective activator of p53 (Ki = 1 µM) and can be used in studies about non-small-cell lung carcinoma. SCH529074 restores mutant p53 function and interrupts HDM2-mediated ubiquitination of wild Type p53. Target: p53. Smiles: CN(C)CCCNc1nc(CN2CCN(CC2)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)nc2ccccc12....
| Keywords: | SCH 529074 |
| Application: | p53 activator |
| CAS | 922150-11-6 |
| MW: | 563.56 D |
From 33.00€
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SCH 529074
Item number: Cay21552-1
SCH 529074 is a small molecule activator of p53, a tumor suppressor that is mutated or non-functional in 50% of human tumors. SCH 529074 restores DNA binding activity and increases DNA binding affinity of two recombinant GST fusion mutant p53 DNA binding domains (R273H and R249S) in an electrophoretic mobility shift...
| Keywords: | N3-[2-[[4-[bis(4-chlorophenyl)methyl]-1-piperazinyl]methyl]-4-quinazolinyl]-N1,N1-dimethyl-1,3-propanediamine |
| Application: | p53 activator |
| CAS | 922150-11-6 |
| MW: | 563.6 D |
From 44.00€
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