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Riviciclib hydrochloride
Item number: TGM-T6924-10mg
Description: Riviciclib hydrochloride (P276-00) is a novel inhibitor of CDK1, CDK4, and CDK9, with IC50 values of 79 nM, 63 nM, and 20 nM, respectively, currently in Phase 2/3. Target: CDK, Apoptosis. Smiles: Cl.CN1CC[C@H]([C@@H]1CO)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl. References: Joshi KS, et al. Mol Cancer Ther,...
| Keywords: | P276-00 |
| Application: | Cdk9 / Cdk4 / Cdk1 inhibitor |
| CAS | 920113-03-7 |
| MW: | 438.3 D |
From 42.00€
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P276-00 (hydrochloride)
Item number: Cay39845-1
P276-00 is an inhibitor of cyclin-dependent kinase 9 (Cdk9), Cdk4, and Cdk1 (IC50s = 0.020, 0.063, and 0.079 µM, respectively). It is selective for these CDKs over Cdk2/cyclin E, Cdk2/cyclin A, Cdk6, and Cdk7 (IC50s = 2.54, 0.224, 0.396, and 2.87 µM, respectively), as well as a panel of eight other kinases. P276-00...
| Keywords: | Riviciclib, 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(2R,3S)-2-(hydroxymethyl)-1-methyl-3-pyrrolidinyl]-4H-1-benzopyran-4-one,... |
| Application: | Cdk9 / Cdk4 / Cdk1 inhibitor |
| CAS | 920113-03-7 |
| MW: | 438.3 D |
From 122.00€
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