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Item number: Cay41839-1

AZD 1656 is an activator of hexokinase-4 (HK4). It activates HK4 and induces glucose phosphorylation in a cell-free assay (EC50 = 61 nM). AZD 1656 (0.3 mg/kg) decreases blood glucose levels in an oral glucose tolerance test (OGTT) in rats. It reduces blood glucose levels and increases plasma insulin levels in mice...

Keywords:	3-[[5-(1-azetidinylcarbonyl)-2-pyrazinyl]oxy]-5-[(1S)-2-methoxy-1-methylethoxy]-N-(5-methyl-2-pyrazinyl)-benzamide
Application:	Hexokinase-4 (HK4, Glucokinase) activator
CAS	919783-22-5
MW:	478.5 D

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AZD-1656

Item number: TGM-T26712-10mg

Description: AZD-1656 is a glucokinase activator (GKA) that can cause dose-limiting hypoglycemia in normal animals used in embryofetal development studies and type 2 diabetes. Target: Glucokinase. Smiles: COC[C@H](C)Oc1cc(Oc2cnc(cn2)C(=O)N2CCC2)cc(c1)C(=O)Nc1cnc(C)cn1. References: Krentz AJ, et al. Effect of...

Keywords:	AZD 1656
CAS	919783-22-5
MW:	478.5 D

From 83.00€ *

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