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Item number: Cay26138-10

GS-143 is an inhibitor of IkappaBalpha ubiquitylation. It inhibits ubiquitylation of phosphorylated IkappaBalpha mediated by the SCFbetaTrCP1 E3 ubiquitin ligase complex in vitro (IC50 = 5.2 µM) and reduces TNF-alpha-induced degradation of phosphorylated IkappaBalpha, but not beta-catenin, another SCFbetaTrCP1...

Keywords:	4-[4-[[5-(2-fluorophenyl)-2-furanyl]methylene]-4,5-dihydro-5-oxo-3-(phenylmethyl)-1H-pyrazol-1-yl]-benzoic acid
Application:	IkappaBalpha ubiquitylation inhibitor
CAS	916232-21-8
MW:	466.5 D

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