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Opaganib
Item number: AG-CR1-3749-M025
Opaganib is a selective inhibitor of sphingosine kinase 2 (SPHK2, Ki = 9.8 µM), a lipid kinase that catalyzes formation of the lipid signaling molecule sphingosine 1-phosphate (S1P). S1P promotes cancer growth, and proliferation and pathological inflammation, including TNF-alpha signaling and other inflammatory...
| Keywords: | 3-(4-Chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide, ABC294640, Yeliva |
| Application: | SPHK2 inhibitor |
| CAS | 915385-81-8 |
| MW: | 380.9 D |
From 99.00€
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Opaganib
Item number: TGM-T6750-100mg
Description: Opaganib (ABC294640) is an orally active and specific sphingosine kinase-2 (SphK2) inhibitor (IC50: 60 µM). Target: S1P Receptor. Smiles: Clc1ccc(cc1)C12CC3CC(CC(C3)(C1)C(=O)NCc1ccncc1)C2. References: French KJ, et al. J Pharmacol Exp Ther. 2010, 333(1), 129-139.
| Keywords: | ABC294640 |
| Application: | SPHK2 inhibitor |
| CAS | 915385-81-8 |
| MW: | 380.91 D |
From 34.00€
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ABC294640
Item number: Cay10587-10
ABC294640 is an inhibitor of sphingosine kinase 2 (SPHK2, Ki = 9.8 µM). It inhibits SPHK2 (IC50 = 60 µM) without affecting SPHK1 activity up to 100 µM but does reduce SPHK1 isoform a (SPHK1a) protein levels in androgen-independent LNCaP (LNCaP-AI) cells via an SPHK1-indirect, proteasomal-dependent mechanism when...
| Keywords: | 3-(4-chlorophenyl)-N-(4-pyridinylmethyl)-tricyclo[3.3.1.13,7]decane-1-carboxamide |
| CAS | 915385-81-8 |
| MW: | 380.9 D |
From 61.00€
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