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Opaganib
Opaganib

Item number: AG-CR1-3749-M025

Opaganib is a selective inhibitor of sphingosine kinase 2 (SPHK2, Ki = 9.8 µM), a lipid kinase that catalyzes formation of the lipid signaling molecule sphingosine 1-phosphate (S1P). S1P promotes cancer growth, and proliferation and pathological inflammation, including TNF-alpha signaling and other inflammatory...
Keywords: 3-(4-Chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide, ABC294640, Yeliva
Application: SPHK2 inhibitor
CAS 915385-81-8
MW: 380.9 D
From 99.00€ *
Review
ABC294640
ABC294640

Item number: Cay10587-10

ABC294640 is an inhibitor of sphingosine kinase 2 (SPHK2, Ki = 9.8 µM). It inhibits SPHK2 (IC50 = 60 µM) without affecting SPHK1 activity up to 100 µM but does reduce SPHK1 isoform a (SPHK1a) protein levels in androgen-independent LNCaP (LNCaP-AI) cells via an SPHK1-indirect, proteasomal-dependent mechanism when...
Keywords: 3-(4-chlorophenyl)-N-(4-pyridinylmethyl)-tricyclo[3.3.1.13,7]decane-1-carboxamide
CAS 915385-81-8
MW: 380.9 D
From 60.00€ *
Review