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AMG-458
Item number: TGM-T6378-5mg
Description: AMG-458 is a potent c-Met inhibitor with Ki of 1.2 nM, ~350-fold selectivity for c-Met than VEGFR2 in cells. Target: c-Met/HGFR. Smiles: COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(CC(C)(C)O)n(-c5ccccc5)c4=O)nc3)ccnc2c1. References: Liu L, et al. J Med Chem, 2008, 51(13), 3688-3691.
| Keywords: | AMG 458 |
| Application: | c-Met inhibitor |
| CAS | 913376-83-7 |
| MW: | 539.58 D |
From 37.00€
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AMG-458
Item number: SYN-1144-M001
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. AMG-458 is a potent inhibitor of c-Met with an IC(50) of 60nM and displays selectivity against VEGFR2.
| Keywords: | AMG458 |
| Application: | MET inhibitor |
| CAS | 913376-83-7 |
| MW: | 539,6 D |
From 193.00€
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AMG 458
Item number: Cay36213-1
AMG 458 is an inhibitor of c-Met (Kis = 1.2, 1.1, 2.2, 4.1, 0.5, and 4.5 nM for wild-type c-Met, c-MetV1092I, c-MetD1228H, c-MetM1250T, c-MetH1094R, and c-MetY1230H, respectively). It inhibits c-Met phosphorylation in PC3 and CT26 cells (IC50s = 60 and 120 nM, respectively). AMG 458 (30 and 100 mg/kg) reduces tumor...
| Keywords: | 2,3-dihydro-1-(2-hydroxy-2-methylpropyl)-N-[5-[(7-methoxy-4-quinolinyl)oxy]-2-pyridinyl]-5-methyl-3-oxo-2-phenyl-1H-pyrazo... |
| Application: | c-Met inhibitor |
| CAS | 913376-83-7 |
| MW: | 539.6 D |
From 92.00€
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