4 products were found matching "912545-86-9"!
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SAG
Item number: Cay11914-1
Smoothened agonist (SAG) is a chlorobenzothiophene-containing compound which acts as a SMO agonist (EC50 = 3 nM) but inhibits hedgehog signaling at high concentrations (>1 µM). It directly binds to SMO and can block SMO inhibition by cyclopamine. Binding of SAG alters the conformation of SMO, leading to its...
| Keywords: | Smoothened Agonist,... |
| Application: | Smo Agonist |
| CAS | 912545-86-9 |
| MW: | 490.1 D |
From 34.00€
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SAG
Item number: TGM-T1779-100mg
Description: SAG (Smoothened Agonist) is a Smo receptor agonist (EC50=3 nM) that is cell-permeable and selective. SAG regulates Smo activity by binding directly to the Smo helix and can activate the Hedgehog signaling pathway. Target: Smo, Hedgehog/Smoothened. Smiles:...
| Keywords: | Smoothened Agonist (SAG) HCl, Smoothened Agonist |
| Application: | Smo Agonist |
| CAS | 912545-86-9 |
| MW: | 490.06 D |
From 47.00€
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SAG
Item number: AG-CR1-3506-M001
Cell permeable smoothened (Smo) agonist - Shown to induce Sonic hedgehog (Shh) pathway activation and counteracts cyclopamine inhibition of Smo - Acts as an activator of Smo at low concentrations and as an inhibitor of Smo at very high concentrations.
| Keywords: | N-Methyl-N'-(3-pyridinylbenzyl)-N'-(3-chlorobenzo[b]thiophene-2-carbonyl)-1,4-diaminocyclohexane |
| Application: | Smo Agonist |
| CAS | 912545-86-9 |
| MW: | 490,1 D |
From 55.00€
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SAG
Item number: LKT-S0224.1
Smoothened agonist.
| Keywords: | 3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[3-(4-pyridinyl)benzyl]-1-benzothiophene-2-carboxamide |
| Application: | Smoothened agonist |
| CAS | 912545-86-9 |
| MW: | 490.06 D |
From 104.00€
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