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Item number: TGM-T10680-100mg

Description: Carebastine, the active metabolite of Ebastine, is an antagonist of the histamine H1 receptor. Target: Histamine Receptor. Smiles: CC(C)(C(O)=O)c1ccc(cc1)C(=O)CCCN1CCC(CC1)OC(c1ccccc1)c1ccccc1. References: De Luisi A, et al. Anti-angiogenic activity of carebastine: a plausible mechanism affecting airway...

CAS	90729-42-3
MW:	499.64 D

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Carebastine

Item number: Cay23076-10

Carebastine is an active metabolite of ebastine (Cay-15372) and a histamine H1 receptor antagonist (Ki = 75.86 nM). It is formed from ebastine by the cytochrome P450 (CYP) isoform CYP3A4. Carebastine inhibits histamine-induced contraction of isolated guinea pig trachea (IC50 = 120 nM). It also inhibits histamine...

Keywords:	4-[4-[4-(diphenylmethoxy)-1-piperidinyl]-1-oxobutyl]-alpha,alpha-dimethyl-benzeneacetic acid
Application:	Active ebastine metabolite
CAS	90729-42-3
MW:	499.6 D

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