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Item number: TGM-T4285-100mg

Description: Crisaborole (AN-2728) is a phosphodiesterase 4 inhibitor. Target: PDE. Smiles: OB1OCc2cc(Oc3ccc(cc3)C#N)ccc12. References: Akama T, et al. Discovery and structure-activity study of a novel benzoxaborole anti-inflammatory agent (AN2728) for the potential topical treatment of psoriasis and atopic...

Keywords:	PF-06930164, AN-2728
Application:	Targets cAMP-specific phosphodiesterase 4 [EC:3.1.4.53] (PDE4)
CAS	906673-24-3
MW:	251.05 D

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AN2728

Item number: Cay21455-100

AN2728 is a boron-based, topical anti-inflammatory agent that inhibits phosphodiesterase 4 (PDE4, IC50 = 0.11 µM). It is less potent against PDE1A, PDE3A, and PDE7A (IC50s = 6.12, 6.41, and 0.73 µM, respectively). AN2728 suppresses the release of the proinflammatory cytokines TNF-alpha, IL-2, INF-gamma, IL-5, and...

Keywords:	Crisaborole, 4-[(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-5-yl)oxy]-benzonitrile
Application:	PDE4 inhibitor
CAS	906673-24-3
MW:	251.1 D

From 84.00€ *

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